Progressive multiple sclerosis, cognitive function, and quality of life

Brain and Behavior
Helene Højsgaard ChowFinn Sellebjerg

Abstract

Patients with progressive multiple sclerosis (MS) often have cognitive impairment in addition to physical impairment. The burden of cognitive and physical impairment progresses over time, and may be major determinants of quality of life. The aim of this study was to assess to which degree quality of life correlates with physical and cognitive function in progressive MS. This is a retrospective study of 52 patients with primary progressive (N = 18) and secondary progressive MS (N = 34). Physical disability was assessed using the Expanded Disability Status Scale, Timed 25 Foot Walk (T25FW) test and 9-Hole Peg Test (9HPT). Cognitive function was assessed using Symbol Digit Modalities Test (SDMT), Paced Auditory Serial Addition Test, and Trail Making Test B (TRAIL-B). In addition, quality of life was assessed by the Short Form 36 (SF-36) questionnaire. Only measures of cognitive function correlated with the overall SF-36 quality of life score and the Mental Component Summary score from the SF-36. The only physical measure that correlated with a measure of quality of life was T25FW test, which correlated with the Physical Component Summary from the SF-36. We found no other significant correlations between the measures of cognitive f...Continue Reading

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Citations

Oct 17, 2019·Journal of Medical Economics·Timo PurmonenJuhani Ruutiainen
Sep 30, 2020·Journal of Advanced Nursing·Loren NilsenRenata C de C P Silveira
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Aug 3, 2021·Journal of Neurology·Gabriel PardoDarin T Okuda
Dec 31, 2021·Multiple Sclerosis : Clinical and Laboratory Research·Marcus W KochGary Cutter

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