Progressive myopathy and defects in the maintenance of myotendinous junctions in mice that lack talin 1 in skeletal muscle.

Development
Francesco J ContiUlrich Müller

Abstract

The development and function of skeletal muscle depend on molecules that connect the muscle fiber cytoskeleton to the extracellular matrix (ECM). beta1 integrins are ECM receptors in skeletal muscle, and mutations that affect the alpha7beta1 integrin cause myopathy in humans. In mice, beta1 integrins control myoblast fusion, the assembly of the muscle fiber cytoskeleton, and the maintenance of myotendinous junctions (MTJs). The effector molecules that mediate beta1 integrin functions in muscle are not known. Previous studies have shown that talin 1 controls the force-dependent assembly of integrin adhesion complexes and regulates the affinity of integrins for ligands. Here we show that talin 1 is essential in skeletal muscle for the maintenance of integrin attachment sites at MTJs. Mice with a skeletal muscle-specific ablation of the talin 1 gene suffer from a progressive myopathy. Surprisingly, myoblast fusion and the assembly of integrin-containing adhesion complexes at costameres and MTJs advance normally in the mutants. However, with progressive ageing, the muscle fiber cytoskeleton detaches from MTJs. Mechanical measurements on isolated muscles show defects in the ability of talin 1-deficient muscle to generate force. Coll...Continue Reading

References

Jun 1, 1991·Journal of Applied Physiology·R L LieberJ Fridén
Oct 1, 1986·The Journal of Cell Biology·J G TidballK Burridge
Jan 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·R B ArmstrongJ A Schwane
Jul 14, 1995·The Journal of Biological Chemistry·H C ChenJ L Guan
May 1, 1995·The Journal of Cell Biology·S N GettnerL F Reichardt
May 27, 1997·Proceedings of the National Academy of Sciences of the United States of America·R O McCann, S W Craig
Oct 23, 1997·The Journal of Cell Biology·V StraubK P Campbell
Nov 14, 1997·Nature Genetics·U MayerK von der Mark
May 20, 1998·Nature Genetics·Y K HayashiK Arahata
Nov 13, 1998·The Journal of Cell Biology·D TavernaR O Hynes
Nov 18, 1998·Current Opinion in Cell Biology·M DurbeejK P Campbell
Dec 3, 1999·Biochemical and Biophysical Research Communications·R O McCann, S W Craig
Feb 19, 2000·Current Opinion in Cell Biology·D R Critchley
Sep 26, 2000·American Journal of Physiology. Cell Physiology·M SamR L Lieber
Nov 21, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·S J MonkleyR Fässler
Jul 27, 2001·The Journal of Biological Chemistry·M LeeJ E Schwarzbauer
Aug 31, 2001·Biochemical and Biophysical Research Communications·S J MonkleyD R Critchley
Nov 21, 2001·Nature Reviews. Molecular Cell Biology·B GeigerK M Yamada
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jun 22, 2002·Current Opinion in Genetics & Development·Madeleine Durbeej, Kevin P Campbell
Nov 1, 2002·Developmental Cell·Nicholas H BrownJames W Fristrom
Nov 26, 2002·The Journal of Cell Biology·Catherine G GalbraithMichael P Sheetz
May 10, 2003·Developmental Cell·Martin SchwanderUlrich Müller
Aug 14, 2003·Journal of Cell Science·Erin J CramJean E Schwarzbauer
Feb 3, 2004·Journal of Cell Science·David A Calderwood
May 26, 2004·Biochemical Society Transactions·D A Calderwood
Sep 15, 2004·Trends in Biochemical Sciences·Iain D Campbell, Mark H Ginsberg
Feb 3, 2005·Nature Reviews. Molecular Cell Biology·Satyajit K MitraDavid D Schlaepfer
Aug 16, 2005·Current Opinion in Cell Biology·Mark H GinsbergSanford J Shattil
May 11, 2006·Journal of Cell Science·Jachinta E RooneyDean J Burkin
Jul 5, 2006·Genes & Development·Xiaozhong Shi, Daniel J Garry

❮ Previous
Next ❯

Citations

May 23, 2013·Nature Communications·Daichi KawaguchiYukiko Gotoh
Oct 24, 2008·Nature Reviews. Molecular Cell Biology·Sandra Iden, John G Collard
Nov 26, 2010·Nature Reviews. Molecular Cell Biology·Juergen A Knoblich
Jul 19, 2013·Nature Reviews. Molecular Cell Biology·David A CalderwoodDavid R Critchley
Dec 26, 2012·The Journal of Biological Chemistry·Ana Maria MansoRobert S Ross
Mar 20, 2009·The Journal of Biological Chemistry·Benjamin T GoultDavid R Critchley
May 19, 2011·Development, Growth & Differentiation·Masatsune Tsujioka
Jun 15, 2011·Molecular and Cellular Biology·Jie LiuShaohua Li
Mar 22, 2014·Nature Reviews. Neuroscience·Tao Sun, Robert F Hevner
May 15, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Klodiana Jani, Frieder Schöck
Feb 18, 2009·The FEBS Journal·Emmanuel DebrandDavid R Critchley
Mar 29, 2014·Birth Defects Research. Part C, Embryo Today : Reviews·Denitsa DochevaAttila Aszodi
Feb 7, 2012·European Journal of Cell Biology·Uta PraekeltSusan J Monkley
Nov 3, 2009·Developmental Biology·Alexander D PerkinsGuy Tanentzapf
Dec 8, 2010·Structure·Nicholas J AnthisIain D Campbell
Nov 18, 2010·Developmental Biology·Susan J MonkleyDavid R Critchley
Aug 29, 2012·Biochemical and Biophysical Research Communications·Emmanuel DebrandDavid R Critchley
May 23, 2013·American Journal of Physiology. Endocrinology and Metabolism·Hannah CrosslandPhilip J Atherton
Sep 2, 2020·Connective Tissue Research·Claire YuanRobert W Grange
Jul 2, 2020·The Journal of Biological Chemistry·Erumbi S RangarajanTina Izard
Mar 21, 2019·Journal of Cell Science·Martinho Soto-RibeiroBernhard Wehrle-Haller
Apr 26, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Kun-Peng FangYe-Ben Qian
Jul 9, 2010·The Journal of Biological Chemistry·Alexandre R GingrasDavid R Critchley
Aug 30, 2014·Journal of Applied Physiology·Gerald S SupinskiLeigh Ann Callahan
Jul 13, 2017·Proceedings of the National Academy of Sciences of the United States of America·Ana Maria MansoRobert S Ross
Feb 16, 2021·Current Tissue Microenvironment Reports·Connor C LeekMegan L Killian
Aug 9, 2019·Biochemistry·Soham ChakrabortyShubhasis Haldar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.