PMID: 8597867Sep 1, 1995Paper

Progressive osseous heteroplasia, uncommon cause of soft tissue ossification: a case report and review of the literature

Pediatric Pathology & Laboratory Medicine : Journal of the Society for Pediatric Pathology, Affiliated with the International Paediatric Pathology Association
R Rodriguez-JuradoA K Poznanski

Abstract

We report a case of an uncommon, recently described disease manifesting shortly after birth, characterized by extensive soft tissue calcification with ossification, progressive osseous heteroplasia. We describe the complex histopathologic patterns present in this case, discuss the main differential diagnoses that the surgical pathologist must consider when confronted by soft tissue ossification, and review the pertinent literature. We conclude that although the morphologic patterns of ossification in progressive osseous heteroplasia are complex and the involvement is extensive, the morphology of the lesions lacks diagnostic specificity. The diagnosis must be based on a consideration of the combined clinical data and radiologic and pathologic findings. This approach alone makes it possible to exclude a number of clinicopathologic entities that manifest with so-called osteoma cutis but whose associated lesions and genetic implications are different.

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Citations

Nov 25, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·F S Kaplan, E M Shore
Jun 9, 1998·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·L TresserraM Tresserra
Sep 22, 2000·Annales de génétique·C StollJ P Bellocq
Mar 15, 2014·Journal of Pediatric Orthopedics. Part B·Dirk E SchranderConstance T R M Schrander-Stumpel
Feb 23, 1999·Pediatric Dermatology·K A JangK C Moon
Jan 11, 2002·The New England Journal of Medicine·Eileen M ShoreFrederick S Kaplan
Oct 9, 2002·Journal of Pediatric Orthopedics. Part B·Osman AynaciKöksal Alpay
May 20, 2000·Clinical Orthopaedics and Related Research·E M ShoreF H Gannon
Feb 28, 2003·American Journal of Medical Genetics. Part a·Russell A FaustFrederick S Kaplan
Oct 20, 1998·Journal of the American Academy of Dermatology·D M Touart, P Sau

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