Progressive Pathological Changes in Neurochemical Profile of the Hippocampus and Early Changes in the Olfactory Bulbs of Tau Transgenic Mice (rTg4510)

Neurochemical Research
Jieun KimPhil Lee

Abstract

Tauopathies such as Alzheimer's disease and frontotemporal lobe degeneration (FTLD-tau) dementia, characterized by pathologic aggregation of the microtubule-associated tau protein and formation of neurofibrillary tangles, have been linked to neurodegeneration and cognitive decline. The early detection of cerebral abnormalities and the identification of biological contributors to the continuous pathologic processes of neurodegeneration in tauopathies critically hinge on sensitive and reliable measures of biomarkers in the living brain. In this study, we measured alterations in a number of key neurochemicals associated with tauopathy-induced neurodegeneration in the hippocampus and the olfactory bulbs of a transgenic mouse model of FTLD-tauopathy, line rTg4510, using in vivo 1H magnetic resonance spectroscopy at 9.4 T. The rTg4510 line develops tauopathy at a young age (4-5 months), reaching a severe stage by 8-12 months of age. Longitudinal measurement of neurochemical concentrations in the hippocampus of mice from 5 to 12 months of age showed significant progressive changes with distinctive disease staging patterns including N-acetylaspartate, myo-inositol, γ-aminobutyric acid, glutathione and glutamine. The accompanying hippoc...Continue Reading

References

Dec 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S W Provencher
Jun 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R Gruetter
Jul 1, 1996·Neurobiology of Aging·C Murphy, S Jinich
Sep 1, 2000·Brain Research. Brain Research Reviews·L BuéeP R Hof
Mar 23, 2001·Neurology·M J Valenzuela, P Sachdev
Aug 10, 2002·The Medical Clinics of North America·John Q Trojanowski, Virginia M Y Lee
Mar 7, 2003·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·S Christen-ZaechJ Miklossy
Aug 11, 2005·Proceedings of the National Academy of Sciences of the United States of America·Malgorzata MarjanskaMichael Garwood
Nov 18, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Martin RamsdenKaren H Ashe
May 3, 2006·The American Journal of Pathology·Tara L SpiresBradley T Hyman
Sep 23, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Vladimír MlynárikRolf Gruetter
Sep 19, 2007·Neurobiology of Aging·Philipp A ThomannJohannes Schröder
Jan 18, 2008·The Journal of Pharmacology and Experimental Therapeutics·Yasuji MatsuokaPaul S Aisen
Jun 6, 2009·Journal of Alzheimer's Disease : JAD·Philipp A ThomannJohannes Schröder
Jan 15, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniel W WessonDonald A Wilson
Jan 23, 2010·Dementia and Geriatric Cognitive Disorders·Shuang-Qing ChenFeng-Chao Zang
Apr 2, 2010·Nature·Alix de CalignonBradley T Hyman
May 4, 2010·Annals of Neurology·Steven E ArnoldJohn Q Trojanowski
Aug 4, 2010·Current Alzheimer Research·K IqbalI Grundke-Iqbal
May 24, 2014·Neuron·Tara L Spires-Jones, Bradley T Hyman
Jun 18, 2014·NeuroImage. Clinical·Tabassum MajidRobia G Pautler
Aug 31, 2014·Trends in Cell Biology·Bess FrostMel B Feany
Sep 17, 2014·Trends in Neurosciences·Hans Zempel, Eckhard Mandelkow
Dec 18, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jack A WellsMark F Lythgoe
Oct 26, 2016·Brain Research Bulletin·Thomas ArendtMax Holzer

❮ Previous
Next ❯

Citations

Aug 15, 2018·Journal of the Neurological Sciences·Michaeline L HebronCharbel E-H Moussa
May 15, 2021·Scientific Reports·Vanessa H BraitAmy Brodtmann

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
chemical exchange saturation transfer
NMR

Software Mentioned

LCModel
FASTMAP
ImageJ
Origin

Related Concepts

Related Feeds

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.

Alzheimer's Disease: Animal Models

Alzheimer's disease is a neurodegenerative disease which can be studied using various experimental systems. This feed focuses on animal models used for Alzheimer's disease research.

Alzheimer's Disease: Early Markers

Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive cognitive and behavioral decline. Targeting markers in the earliest stages of the disease may mitigate the progression of AD. This feed focuses on early diagnosis and markers, as well as environmental, pharmacological, and drug-response biomarkers associated with this disease.