PMID: 8972546Dec 1, 1996Paper

Progressive ratio and behavioral economic evaluation of the reinforcing efficacy of orally delivered phencyclidine and ethanol in monkeys: effects of feeding conditions

Psychopharmacology
J S Rodefer, M E Carroll

Abstract

The effect of feeding conditions on the reinforcing efficacy of orally-delivered drugs was evaluated using a progressive-ratio (PR) paradigm and a behavioral economic analysis of demand. Seven monkeys self-administered phencyclidine (PCP) (0.06, 0.12, 0.25, 0.5, and 1.0 mg/ml) or ethanol (2, 4, 8, 16, and 32% wt/vol) and concurrent water from two drinking spouts under concurrent PR schedules. The ratios increased from 8 to 4096, and 40 liquid deliveries were available after completion of each ratio schedule. The entire range of drug concentrations was presented in nonsystematic order under two feeding conditions, food restriction and food satiation. Drug maintained responses, deliveries and break points were significantly greater than those maintained by water. Food restriction significantly increased the rate of PCP-maintained responses, deliveries and PR break points over the food satiation baseline. There was also a significant interaction between feeding condition and drug concentration. Although ethanol-maintained responses, liquid deliveries and break points consistently increased in five of seven monkeys during food restriction, only drug concentration produced significant differences in these measures. Using break point...Continue Reading

Citations

Nov 27, 2004·Psychopharmacology·Lawrence J CheskinDavid A Gorelick
May 20, 1999·European Journal of Pharmacology·J E GallateI S McGregor
Sep 5, 2003·Physiology & Behavior·Anthony Sclafani, Karen Ackroff
Mar 1, 2006·Experimental and Clinical Psychopharmacology·Jennifer L PerryMarilyn E Carroll
Jun 16, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Therese A KostenPriscilla Kehoe
Nov 1, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Magalie Lenoir, Serge H Ahmed
Nov 5, 1999·Alcoholism, Clinical and Experimental Research·C L Czachowski, H H Samson
Mar 10, 2001·Alcoholism, Clinical and Experimental Research·C L CzachowskiS N Katner
Aug 1, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Pietro CottoneEric P Zorrilla
Nov 13, 2013·Psychopharmacology·Natalie R Bruner, Matthew W Johnson
Mar 19, 2014·Psychopharmacology·Joshua A Peck, Robert Ranaldi
May 1, 2008·Alcoholism, Clinical and Experimental Research·Michael R WeedRobert D Hienz
Mar 25, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M SolinasS R Goldberg
Feb 8, 2002·Journal of the Experimental Analysis of Behavior·Robert B StewartRichard A Meisch
Apr 11, 2006·Journal of the Experimental Analysis of Behavior·Matthew W Johnson, Warren K Bickel
Mar 25, 2010·Pharmacology, Biochemistry, and Behavior·Suzanne M DrosteJoshua S Rodefer

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