Progressive resistance training in head and neck cancer patients undergoing concomitant chemoradiotherapy

Laryngoscope Investigative Otolaryngology
Camilla K LonkvistJulie Gehl

Abstract

Patients with head and neck squamous cell carcinoma undergoing concomitant chemoradiotherapy (CCRT) frequently experience weight loss, especially loss of lean body mass (LBM), and reduced functional performance. This study investigated whether a 12-week hospital-based progressive resistance training (PRT) program during CCRT is feasible in the clinical setting before planning initiation of a larger randomized study which is the long-term goal. Prospective pilot study. Twelve patients receiving CCRT were planned to attend a 12-week PRT program. Primary endpoint was feasibility measured as attendance to training sessions. Secondary endpoints included changes in functional performance, muscle strength, and body composition measured by Dual-energy X-ray Absorptiometry (DXA) scans. Furthermore, sarcomeric protein content, pentose phosphate pathway (PPP) activity, and glycolysis were determined in muscle biopsies. Twelve patients with p16 positive oropharyngeal cancer were enrolled. The primary endpoint was met with 9 of the 12 patients completing at least 25 of 36 planned training sessions. The mean attendance rate was 77%. Functional performance was maintained during the treatment period and increased during follow-up (p < 0.01). S...Continue Reading

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Citations

Mar 1, 2019·Journal of Cachexia, Sarcopenia and Muscle·Miguel S Conceição, Carlos Ugrinowitsch
Dec 4, 2019·Frontiers in Oncology·Inês Almada-CorreiaPaula Ravasco
Feb 5, 2021·International Journal of Environmental Research and Public Health·Kuan-Yin LinKun-Ling Tsai
Mar 21, 2021·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Jon CacicedoMaria Soledad Arietaleanizbeaskoa
Aug 15, 2021·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Joanne S HiattJudith Bauer

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Methods Mentioned

BETA
biopsies
biopsy

Clinical Trials Mentioned

NCT02068950

Software Mentioned

CTCAE
SPSS
MaxQuant

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