Progressive restriction of cell fates in relation to neuroepithelial cell mingling in the mouse cerebellum

Developmental Biology
Luc Mathis, Jean-François Nicolas

Abstract

Neurogenesis in the cerebellum proceeds through a temporal series of cell production from two separate epithelia, the ventricular zone (VZ) and the external granule cell layer (EGL). Using the laacZ cell lineage tracer in transgenic mice, we describe cellular clones whose dates of birth span the entire period of cerebellar development and deduce a sequence of cell dispersion leading to the final allocation of cells in the cerebellum. Clones probably labeled early during neural tube formation show that individual progenitors can give rise to all cerebellar cell types. The distribution of clonally related granule cells in these clones indicates a mediolateral organization of EGL progenitors already established before the allocation of the EGL progenitors to the cerebellum. Clones restricted to the cerebellar VZ show that the VZ derives progenitors for deep nuclei and multipotent cortical progenitors, which lose their systematic lineage relationship when longitudinal cell intermingling in the cerebellar VZ becomes more limited. The small clones also show that cell dispersion is radial in the internal granule layer and tangential in the molecular layer. Together, the data demonstrate the broad maintenance of the relative order of c...Continue Reading

References

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Jan 1, 1997·Developmental Neuroscience·J E GoldmanJ Gensert
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Sep 26, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·L Mathis, J F Nicolas
Jan 1, 1989·The European Journal of Neuroscience·Salvador Martinez, Rosa-Magda Alvarado-Mallart

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Citations

Feb 8, 2008·Bulletin of Experimental Biology and Medicine·V S RepinG T Sukhikh
Aug 29, 2013·Progress in Neurobiology·Annalisa Buffo, Ferdinando Rossi
Mar 13, 2012·Development, Growth & Differentiation·Mikio Hoshino
Mar 7, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·J Sebastian Espinosa, Liqun Luo
Feb 9, 2010·Trends in Neurosciences·Alain Chédotal
Apr 15, 2010·Developmental Biology·Shuichi KaniMasahiko Hibi
Jul 4, 2006·Brain Research·Yukiteru MaedaTakeshi Tokuhisa
May 4, 2010·Developmental Biology·Moises MalloJacqueline Deschamps
Feb 11, 2014·Neuron·Karine LoulierJean Livet
Sep 18, 2009·Developmental Cell·Elena TzouanacouJean-François Nicolas
Oct 4, 2007·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Barbara Carletti, Ferdinando Rossi
Jan 29, 2005·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Patricia G MelloyMary E Desmond

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