Progressive, severe lung injury secondary to the interaction of insults in gastric aspiration

Experimental Lung Research
Paul R KnightBruce A Holm

Abstract

This study examines lung injury and inflammation over 24 hours following intratracheal instillation of hydrochloric acid (acid), small nonacidic gastric particles (SNAP), or combined acid and small particles (CASP) in adult rats. The severity and duration of injury was significantly greater for CASP compared to acid or SNAP based on PaO2/FiO2, bronchoalveolar lavage (BAL) albumin, and BAL cell numbers. The inflammatory response associated with aspiration injury from CASP was distinct in several respects. Tumor necrosis factor (TNF)-alpha was greatly reduced in CASP compared to SNAP or acid, whereas interleukin (IL)-1beta was increased. Levels of cytokine-induced neutrophil chemoattractant (CINC)-1, monocyte chemoattractant protein (MCP)-1, and IL-10 in lavage were also significantly increased in animals injured with CASP compared to other forms of aspiration. Statistical analysis showed that BAL levels of IL-10 correlated most strongly with albumin leakage in aspiration-injured animals at 6 and 24 hours, followed by BAL levels of MCP-1. Additional cytokine cluster analyses indicated that levels of MCP-1 and CINC-1 in BAL from all injured animals were strongly correlated with inflammatory neutrophil numbers at 6 and 24 hours pos...Continue Reading

References

Aug 1, 1992·Journal of Applied Physiology·G GoldmanH B Hechtman
Apr 1, 1991·Journal of Applied Physiology·G GoldmanH B Hechtman
Jan 1, 1986·Acta Anaesthesiologica Scandinavica·G L OlssonK Hambraeus-Jonzon
May 1, 1983·Annals of Internal Medicine·A A FowlerT M Hyers
Jul 1, 1982·American Journal of Surgery·P E PepeC J Carrico
Aug 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·F A GrimbertA E Taylor
Jul 1, 1995·The Journal of Clinical Investigation·H G FolkessonV C Broaddus
Feb 1, 1995·Anesthesiology·I KudohJ Wiener-Kronish
Jun 15, 1997·The Journal of Clinical Investigation·D A ZismanT J Standiford
Aug 2, 2000·Critical Care Medicine·T P ShanleyP R Knight
Mar 3, 2001·The New England Journal of Medicine·P E Marik
Aug 1, 1946·American Journal of Obstetrics and Gynecology·C L MENDELSON

❮ Previous
Next ❯

Citations

Jan 26, 2011·Critical Care Medicine·Krishnan RaghavendranPaul R Knight
Dec 17, 2009·The Journal of Trauma·Krishnan RaghavendranPaul R Knight
Jan 2, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jean A NemzekAladdein Mattar
Mar 26, 2013·American Journal of Respiratory Cell and Molecular Biology·Bethany B MooreCory M Hogaboam
May 9, 2014·Chest·Augustine LeeUNKNOWN United States Critical Illness and Injury Trials Group
Oct 5, 2010·Nanomedicine : Nanotechnology, Biology, and Medicine·Krishnan V ChakravarthyPaul R Knight
Oct 29, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Mark F SandsStanley A Schwartz
Sep 1, 2015·The American Journal of Pathology·Joaquín D AraosGisella R Borzone
May 9, 2006·Paediatric Anaesthesia·Thomas Howlett, Jerrold Lerman
Nov 4, 2006·Best Practice & Research. Clinical Anaesthesiology·Matthias JandaGabriele F E Nöldge-Schomburg
Apr 12, 2016·Journal of Cellular and Molecular Medicine·Jing ZhouShanqun Li
Mar 26, 2013·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Shyh-Ren ChiangYin-Ching Chuang
Jul 17, 2016·Respiratory Research·A P HackettP S McNamara
Aug 11, 2007·Immunological Investigations·Nader D NaderPaul R Knight
Jul 22, 2017·Anesthesia and Analgesia·Sekar S Bhavani, Basem B Abdelmalak
Nov 6, 2018·Minerva anestesiologica·Michael V PrestaBasem B Abdelmalak
Jul 23, 2013·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Ryan A WaybrightThomas J Johnson
Mar 11, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Bruce A DavidsonRobert H Notter
Apr 5, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Thomas A RussoPaul R Knight
Dec 16, 2010·European Journal of Anaesthesiology·Beatrice Beck-Schimmer, John M Bonvini
Oct 26, 2005·Anesthesia and Analgesia·Krishnan RaghavendranPaul R Knight
Feb 20, 2018·The Open Respiratory Medicine Journal·E B HuntD M Murphy
Nov 23, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Brahm H SegalPaul R Knight
Apr 8, 2010·Expert Review of Molecular Diagnostics·Philippe Abou JaoudeAli A El-Solh
Oct 15, 2014·Journal of Pediatric Gastroenterology and Nutrition·Hany AlyAmany Elwakkad
Jun 19, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·F PuigA Artigas
Mar 22, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Krishnan RaghavendranPaul R Knight
Nov 13, 2010·Intensive Care Medicine·Bing HanMingyao Liu
Jan 21, 2015·Anesthesiology·John Kyle Bohman
Sep 8, 2017·Journal of Dental Anesthesia and Pain Medicine·Young Gon SonHo Geol Ryu
Sep 2, 2018·Respiratory Research·Pedro AyalaGisella R Borzone
Jan 9, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bruce A DavidsonBrahm H Segal

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.

Related Papers

American Journal of Physiology. Lung Cellular and Molecular Physiology
Bruce A DavidsonRobert H Notter
American Journal of Physiology. Lung Cellular and Molecular Physiology
Krishnan RaghavendranPaul R Knight
The Journal of Pain : Official Journal of the American Pain Society
L C LoramD Mitchell
© 2021 Meta ULC. All rights reserved