Progressive supranuclear palsy: what do we know about it?

Current Medicinal Chemistry
Ling LongQing Wang

Abstract

Progressive supranuclear palsy (PSP) is a progressive tauopathy characterized by supranuclear ophthalmoplegia, pseudobulbar palsy, dysarthria, axial rigidity, frontal lobe dysfunction, and dementia. The typical pathology includes neuronal loss, gliosis and microtubule-associated protein tau (MAPT)-positive inclusions in neurons and glial cells, primarily in basal ganglia, brainstem and cerebellum. The pathogenesis of PSP is not yet completely understood; however, there are several hypotheses. This article reviews the present knowledge about PSP, and the concepts underlying mitochondrial dysfunction, lipoperoxidation, and gene mutations. The clinical features of PSP are also discussed; these include vertical gaze palsy, pseudobulbar palsy, aphasia, dysarthria, axial rigidity, and neuropsychiatric symptoms, such as amnesia, irritability, loss of interest, and dementia. In terms of diagnosis, there is considerable interest in neuroimaging for detecting PSP; therefore, neuroimaging techniques such as magnetic resonance imaging (MRI) and [18F]- fluorodeoxyglucose positron-emission tomography (FDG-PET) are reviewed. A definitive diagnosis of PSP depends on pathology, and the introduction of new clinical subtypes challenges presents t...Continue Reading

Citations

Jun 7, 2016·Acta Neurologica Scandinavica·E MäkinenV Kaasinen
Mar 5, 2018·Journal of Cellular and Molecular Medicine·Alessandra Maria CalogeroGianni Pezzoli
Feb 8, 2018·Molecular Neurobiology·Laura KayMeera Soundararajan
Jul 11, 2020·American Journal of Alzheimer's Disease and Other Dementias·Sunil Pradhan, Ruchika Tandon
Dec 27, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Céline VermeirenMichel Gillard
Apr 13, 2021·Brain : a Journal of Neurology·Wanlin YangQing Wang
Oct 16, 2021·Alzheimer Disease and Associated Disorders·Petros StamatelosSokratis G Papageorgiou

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