PMID: 3384013Apr 1, 1988Paper

Progressive ultrastructural damage and thickening of the basement membrane of the retinal pigment epithelium in spontaneously diabetic BB rats

Experimental Eye Research
S A VinoresS H Blaydes

Abstract

Ultrastructural examination of the neural retina and retinal pigment epithelium was performed in spontaneously diabetic BB rats and non-diabetic littermate controls at various time points during the course of diabetes. Four types of progressive changes occur in diabetic rats: (1) There is a progressive thickening of the basal laminae of the retinal pigment epithelium and the retinal capillaries. (2) In addition to this thickening, there is a progressive, often focal, thickening of the rest of Bruch's membrane, and by 11 1/2 months it contains numerous randomly oriented collagen fibrils. (3) There are progressive ultrastructural changes in retinal pigment epithelial cells consisting of marked dilation of the basal infoldings, the formation of large vacuoles and cell swelling. (4) Rare degenerative changes were noted in retinal capillary pericytes. Since non-diabetic littermates do not show comparable changes, it is likely that they are diabetes-related, suggesting that progressive damage to the retinal pigment epithelium may occur during the course of diabetes.

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Citations

May 4, 2011·Japanese Journal of Ophthalmology·Tadanobu YoshikawaKanji Takahashi
Feb 10, 2006·Retina·Dalia B Jensen, Lars L Knudsen
Aug 1, 1995·The British Journal of Ophthalmology·D WeinbergerY Yassur
Mar 12, 2004·American Journal of Ophthalmology·Ronald KleinMylan R Vannewkirk
Nov 29, 2005·Advanced Drug Delivery Reviews·Amol D Kulkarni, Baruch D Kuppermann
Nov 6, 2002·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Yoshinori AizuHachiro Nakagawa
Mar 1, 1989·Current Eye Research·M E Fitzgerald, R B Caldwell
Feb 1, 1989·Diabetes/metabolism Reviews·C W Marano, F M Matschinsky
Jul 23, 2021·Progress in Retinal and Eye Research·Raphael LejoyeuxJay Chhablani

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