Progressive vascular remodeling and reduced neointimal formation after placement of a thermoelastic self-expanding nitinol stent in an experimental model

Catheterization and Cardiovascular Diagnosis
A J CarterR Virmani

Abstract

Despite the improvements afforded by intracoronary stenting, restenosis remains a significant problem. The optimal physical properties of a stent have not been defined. We compared the vascular response to a thermoelastic self-expanding nitinol stent with a balloon-expandable tubular slotted stainless steel stent in normal porcine coronary arteries. Twenty-two stents (11 nitinol and 11 tubular slotted) were implanted in 11 miniature swine. The nitinol stents were deployed using the intrinsic thermal properties of the metal, without adjunctive balloon dilation. The tubular slotted stents were implanted using a noncompliant balloon with a mean inflation pressure of 12 atm. Intravascular ultrasound (IVUS) and histology were used to evaluate the vascular response to the stents. The mean cross-sectional area (CSA) of the nitinol stents (mm2) as measured by IVUS increased from 8.13 +/- 1.09 at implant to 9.10 +/- 0.99 after 28 days (P = 0.038), while the mean CSA of the tubular slotted stents was unchanged (7.84 +/- 1.39 mm2 vs. 7.10 +/- 1.07 mm2, P = 0.25). On histology at 3 days, the tubular slotted stents had more inflammatory cells adjacent to the stent wires (5.7 +/- 1.5 cells/0.1 mm2) than the nitinol (3.9 +/- 1.3 cells/0.1 mm2...Continue Reading

References

Feb 1, 1992·Journal of the American College of Cardiology·R S SchwartzD R Holmes
Jan 3, 1991·The New England Journal of Medicine·P W SerruysL Kappenberger
Mar 19, 1987·The New England Journal of Medicine·U SigwartL Kappenberger
Feb 15, 1995·The American Journal of Cardiology·J A PainterM B Leon
Oct 1, 1994·Journal of the American College of Cardiology·S L GoldbergJ M Tobis
Sep 1, 1994·Journal of Vascular and Interventional Radiology : JVIR·F FlueckigerG Kleinhappl
Aug 14, 1996·The American Journal of Cardiology·P W Serruys, M J Kutryk
Sep 15, 1996·Circulation·E R Edelman, C Rogers

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Citations

Apr 17, 2009·AJNR. American Journal of Neuroradiology·D F KallmesH J Cloft
Jun 18, 2009·Cardiovascular and Interventional Radiology·Frank AhlhelmWolfgang Reith
Feb 10, 2010·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Michael JonerRenu Virmani
Nov 7, 2002·Circulation Journal : Official Journal of the Japanese Circulation Society·Yoshihisa KinoshitaKoichi Yokoya
Mar 26, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Yoshitaka IsoTakashi Katagiri
Oct 7, 2004·Journal of Vascular and Interventional Radiology : JVIR·Patrick Michael Vogel, Carol Parise
Jun 2, 2000·Journal of Vascular and Interventional Radiology : JVIR·S H DudaC D Claussen
Oct 19, 1999·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·S VerheyeN A Chronos
Aug 10, 2000·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·I P KayP W Serruys
Jul 18, 2001·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·A J CarterA C Yeung
Jun 19, 2004·International Journal of Cardiovascular Interventions·Stefan VerheyeMark Kockx
Jul 19, 2002·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Renu Virmani
Oct 10, 2003·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Benjamin Thierry, Maryam Tabrizian
Oct 3, 2002·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Brett M SasseenTheodore A Bass
Jul 1, 2006·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Mehmet CilingirogluSteven R Bailey
Nov 5, 2005·Journal of Biomedical Materials Research. Part a·Manfred F Maitz, Natalia Shevchenko
Aug 27, 2005·Journal of Biomechanical Engineering·Lorenza PetriniFerdinando Auricchio
Jun 2, 2009·Cardiovascular and Interventional Radiology·Hugh Q ZhaoLewis B Schwartz
May 25, 2005·Annals of Biomedical Engineering·Taewon SeoAbdul I Barakat
Feb 19, 2000·Current Opinion in Lipidology·R Virmani, A Farb
Oct 16, 2004·International Journal of Cardiovascular Interventions·Rona ShoftiRafael Beyar
Jul 18, 2001·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·A J TaylorR Virmani
Jun 22, 2000·The Journal of the American Dental Association·H W Roberts, S W Redding

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