Progressive vascular remodelling, endothelial dysfunction and stiffness in mesenteric resistance arteries in a rodent model of chronic kidney disease

Vascular Pharmacology
K J QuekJacqueline K Phillips

Abstract

Chronic kidney disease (CKD) and hypertension are co-morbid conditions both associated with altered resistance artery structure, biomechanics and function. We examined these characteristics in mesenteric artery together with renal function and systolic blood pressure (SBP) changes in the Lewis polycystic kidney (LPK) rat model of CKD. Animals were studied at early (6-weeks), intermediate (12-weeks), and late (18-weeks) time-points (n=21), relative to age-matched Lewis controls (n=29). At 12 and 18-weeks, LPK arteries exhibited eutrophic and hypertrophic inward remodelling characterised by thickened medial smooth muscle, decreased lumen diameter, and unchanged or increased media cross-sectional area, respectively. At these later time points, endothelium-dependent vasorelaxation was also compromised, associated with impaired endothelium-dependent hyperpolarisation and reduced nitric oxide synthase activity. Stiffness, elastic-modulus/stress slopes and collagen/elastin ratios were increased in 6 and 18-week-old-LPK, in contrast to greater arterial compliance at 12weeks. Multiple linear regression analysis highlighted SBP as the main predictor of wall-lumen ratio (r=0.536, P<0.001 n=46 pairs). Concentration-response curves revealed...Continue Reading

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Citations

Sep 25, 2017·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Nadine Khouzam, Katherine Wesseling-Perry
Mar 17, 2020·Journal of Atherosclerosis and Thrombosis·Pasquale EspositoGiacomo Garibotto
Mar 28, 2020·American Journal of Hypertension·Ko Jin QuekJacqueline K Phillips
Apr 11, 2020·KI Reports·Ivana Y Kuo, Arlene B Chapman

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