PMID: 9160034May 1, 1997Paper

Progressive visual loss from giant cell arteritis despite high-dose intravenous methylprednisolone

Ophthalmology
W T Cornblath, E R Eggenberger

Abstract

Giant cell arteritis (GCA) often presents with devastating visual loss in the elderly, yet the ideal treatment is unknown. The disease most often has been treated with oral prednisone, although recently the use of the high-dose intravenous methylprednisolone (IVMP) has been reported to enhance visual recovery. The authors reviewed patient charts from two university-based neuroophthalmology services and reviewed all previously reported cases of GCA treated with IVMP. Four patients with GCA exhibited severe, progressive visual loss after at least 48 hours of high-dose IVMP. A fifth patient had further visual loss in one eye and improvement in the other eye after 24 hours of IVMP. In previous reports of IVMP treatment in GCA, four patients lost vision and 14 patients recovered vision. The authors review the details of these reports. The results of IVMP treatment of patients with visual loss from GCA are similar to the results of treatment with oral corticosteroids, with IVMP treatment being more costly and having a small risk of sudden death. The optimal dosage and route of corticosteroid treatment for GCA with visual loss remain elusive and warrant a treatment trial.

References

Jul 1, 1991·The British Journal of Ophthalmology·J P Diamond
Jan 13, 1990·BMJ : British Medical Journal·P V Gardiner, I D Griffiths
Jan 1, 1987·The American Journal of Emergency Medicine·D Doezema
Jan 1, 1986·The American Journal of Medicine·S I RosenfeldE M Cohn
Nov 1, 1983·Transplantation·J F ThompsonP J Morris
Jul 1, 1994·Archives of Family Medicine·D A WeinbergT M Bosley
Apr 28, 1993·JAMA : the Journal of the American Medical Association·G A ChrousosP A Cleary
Apr 1, 1993·Ophthalmology·P D AielloG G Hunder

❮ Previous
Next ❯

Citations

Dec 11, 2003·Current Treatment Options in Neurology·Jennifer K. Hall, Laura J. Balcer
Nov 1, 2011·Current Treatment Options in Neurology·Ryan A ScheurerMichael S Lee
May 12, 2005·Ophthalmology·Helen Danesh-MeyerGreg G Gamble
Jun 12, 2003·Ophthalmology·Sohan Singh Hayreh, Bridget Zimmerman
Jul 27, 2001·Neurologic Clinics·T Z MovsasN J Volpe
Jun 12, 2001·The Journal of Emergency Medicine·M T Bhatti
Apr 5, 2001·Progress in Retinal and Eye Research·J FlammerT Resink
Jul 2, 2005·The Neurologist·Valerie Purvin, Aki Kawasaki
Jul 9, 2009·International Ophthalmology Clinics·Derek W DelMonte, M Tariq Bhatti
Aug 24, 2012·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Sohan Singh Hayreh, Valérie Biousse
Jun 18, 1998·Australian and New Zealand Journal of Ophthalmology·A K KwokC T Liew
Apr 16, 2002·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Andrew S Gurwood, Kelly A Malloy
Jan 23, 2004·The British Journal of Ophthalmology·L M BuonoP J Savino
Aug 25, 2001·The British Journal of Ophthalmology·C C ChanJ O'Day
Sep 19, 2003·Postgraduate Medical Journal·J M Calvo-Romero
Mar 26, 2013·La Revue de médecine interne·E LiozonP-Y Robert
Jul 10, 2009·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·S S L ChewH V Danesh-Meyer
May 27, 2008·Survey of Ophthalmology·Edlira BendoRod Foroozan
May 11, 2006·Neurologic Clinics·Andrew G Lee, Paul W Brazis
Apr 13, 2004·Arthritis and Rheumatism·Gideon NesherMoshe Sonnenblick
Nov 9, 2004·Survey of Ophthalmology·David van der StraatenJustin O'Day
Sep 24, 2015·Current Opinion in Ophthalmology·Sumayya J AlmarzouqiAndrew G Lee
Sep 6, 2005·Survey of Ophthalmology·Waheeda Rahman, Farooq Z Rahman
Jan 16, 1999·Emergency Medicine Clinics of North America·A Morgan, R R Hemphill
Oct 22, 2008·Acta Ophthalmologica·Aki Kawasaki, Valerie Purvin
Jan 6, 2001·The Journal of the American Dental Association·D T AllenJ C Allen
Mar 6, 2015·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Rebecca C StacyJoseph F Rizzo
Nov 26, 1999·Journal of the American Geriatrics Society·A G Lee, P W Brazis
Jul 7, 2017·Nature Reviews. Rheumatology·Alessandra SorianoCarlo Salvarani
Nov 15, 2003·Current Opinion in Ophthalmology·Grant W Su, Rod Foroozan
Apr 22, 2006·Clinical & Experimental Ophthalmology·Stuart C CarrollHelen V Danesh-Meyer
Dec 6, 2001·Current Opinion in Ophthalmology·M T Bhatti, H Tabandeh
Jun 6, 2003·Clinical & Experimental Ophthalmology·Colin C K Chan, Justin O'Day
Apr 8, 2004·Clinical & Experimental Ophthalmology·Andrew F Riley, Neil S Aburn
Mar 9, 2019·BMJ Case Reports·Anouk Le GoueffDavid Jayne
Aug 23, 2019·Rheumatology Advances in Practice·Chetan MukhtyarColin Jones
Sep 30, 2009·European Journal of Ophthalmology·Miltiadis PapathanassiouIoannis Vergados
Jan 12, 2021·Clinical & Experimental Ophthalmology·Sumu SimonPravin Hissaria

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.