Prohemostatic and antithrombin activities of Ankaferd hemostat are linked to fibrinogen gamma chain and prothrombin by functional proteomic analyses

Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Duygu Ozel-DemiralpNejat Akar

Abstract

Ankaferd blood stopper (ABS) is a novel topical hemostatic agent of plant origin registered for the management of external hemorrhages, in Turkey. The ABS-induced formation of the protein network with vital erythroid aggregation covers the whole physiological hemostatic process. The aim of this study is to assess prohemostatic and antithrombin effects of ABS on the basis of functional proteomic analyses performed in ABS-treated plasma and serum samples based on the previous hypotheses about ABS action. For this purpose, serum and plasma proteins were separated by 2-dimensional (2D) gel electrophoresis, and proteins were identified using reference plasma gel on Swiss-2DPAGE database. Our results indicated that fibrinogen gamma chain and prothrombin levels just initially decreased first and thereafter enhanced following the ABS exposure. Dual effects of ABS on those critical hemostatic molecules seem to be associated with prohemostatic and antithrombin activities of the hemostatic agent.

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Citations

Feb 5, 2014·Archivos de bronconeumología·Oguz UzunIbrahim C Haznedaroglu
Mar 1, 2016·BioMed Research International·Ahmet KolumanIbrahim C Haznedaroglu
Aug 31, 2013·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Gulden CancanMurat Ozcan
Nov 8, 2017·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Afife Gulec, Sukru Gulec
Mar 16, 2017·SAGE Open Medicine·Seyhan TurkIbrahim Celalettin Haznedaroglu
Jul 25, 2015·Journal of Pediatric Hematology/oncology·Kamuran KaramanMesut Garipardiç
Feb 28, 2019·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Mufide OkayIbrahim C Haznedaroglu

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BETA
Electrophoresis

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PDQuest

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