Prohibitin is involved in mitochondrial biogenesis in plants

The Plant Journal : for Cell and Molecular Biology
Chang Sook AhnHyun-Sook Pai

Abstract

Prohibitin, which consists of two subunits PHB1 and PHB2, plays a role in cell-cycle progression, senescence, apoptosis, and maintenance of mitochondrial function in mammals and yeast. In this study, we examined the role of prohibitins in plants by using virus-induced gene silencing (VIGS) of two prohibitin subunit genes of Nicotiana benthamiana, designated NbPHB1 and NbPHB2. NbPHB1 and NbPHB2 were targeted to the mitochondria, and their gene expression was suppressed during senescence. VIGS of NbPHB2 caused severe growth inhibition, leaf yellowing and symptoms of cell death, whereas VIGS of NbPHB1 resulted in a milder phenotype. At the cellular level, depletion of these subunits affected mitochondria by severely reducing their number and/or mass, and by causing morphological and physiological abnormalities. Suppression of prohibitin function resulted in a 10- to 20-fold higher production of reactive oxygen species and induced premature leaf senescence. Finally, disruption of prohibitin function rendered the plants more susceptible to various oxidative stress-inducing reagents, including H(2)O(2), paraquat, antimycin A and salicylic acid. These results suggest that prohibitins play a crucial role in mitochondrial biogenesis and...Continue Reading

References

May 8, 1993·International Journal of Cancer. Journal International Du Cancer·W D FoulkesJ Trowsdale
Aug 1, 1997·Current Biology : CB·P J CoatesP A Hall
Aug 28, 1998·Science·D R Green, J C Reed
Apr 17, 1999·The Plant Journal : for Cell and Molecular Biology·A TakahashiK Shimamoto
Apr 17, 1999·Molecular and Cellular Biology·G SteglichT Langer
May 7, 1999·The Plant Journal : for Cell and Molecular Biology·M V Rao, K R Davis
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·D P MaxwellL McIntosh
Feb 13, 2001·The Plant Journal : for Cell and Molecular Biology·P C Bethke, R L Jones
Feb 13, 2001·The Plant Journal : for Cell and Molecular Biology·F RatcliffD C Baulcombe
Aug 9, 2001·Proceedings of the National Academy of Sciences of the United States of America·H OubrahimP B Chock
Jan 5, 2002·Analytical Biochemistry·H ZhangG E Gibson
Jun 18, 2002·The EMBO Journal·Sheng WangDouglas V Faller
Feb 1, 1997·Plant Physiology·G. M. Pastori, L. A. Del Rio
Sep 19, 2002·Protein Science : a Publication of the Protein Society·Jaap W BackAnton O Muijsers
Mar 1, 2003·The Plant Journal : for Cell and Molecular Biology·Sang Sook LeeHyun-Sook Pai
Mar 15, 2003·The Journal of Biological Chemistry·Moonil KimHyun-Sook Pai
Jun 10, 2003·The Journal of Biological Chemistry·Marta Artal-SanzLeo G J Nijtmans
Aug 30, 2003·Journal of Experimental Botany·Saeid NavabpourVicky Buchanan-Wollaston
Sep 23, 2003·The Journal of Biological Chemistry·Gina FusaroSrikumar Chellappan
Jun 1, 1997·Annual Review of Plant Physiology and Plant Molecular Biology·Chris Lamb, Richard A. Dixon
May 26, 2004·Brain Research·Rosa A González-PoloJosé M Fuentes
Sep 16, 2004·The Plant Cell·Hye Sun ChoHyun-Sook Pai
Nov 5, 2004·Molecular Biology of the Cell·Takashi TatsutaThomas Langer
Sep 20, 2005·The Plant Journal : for Cell and Molecular Biology·Jen-Chih ChenMichael S Reid

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Citations

Jul 16, 2011·The Journal of Biological Chemistry·Yiping QiFumiaki Katagiri
Oct 21, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Graham M StrubSarah Spiegel
Apr 22, 2008·BMC Plant Biology·Alexandre MaréchalNormand Brisson
Jan 13, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ping ZhouCostantino Iadecola
Mar 15, 2012·Science China. Life Sciences·Changjun HuangXueping Zhou
Sep 8, 2009·Trends in Endocrinology and Metabolism : TEM·Marta Artal-Sanz, Nektarios Tavernarakis
Sep 29, 2009·Plant Physiology and Biochemistry : PPB·Arunima Purkayastha, Indranil Dasgupta
Jun 11, 2008·Journal of Plant Physiology·Muthappa Senthil-KumarMakarla Udayakumar
May 23, 2008·Physiologia Plantarum·Danilo C CentenoAlisdair R Fernie
Apr 12, 2007·Proteins·Anja WinterAndreas Hofmann
Sep 22, 2007·The Plant Journal : for Cell and Molecular Biology·Olivier Van AkenFrank Van Breusegem
Dec 19, 2013·Journal of Cellular Physiology·Indrajit ChowdhuryKelwyn Thomas
Jan 19, 2013·Journal of Receptor and Signal Transduction Research·Tian-Biao Zhou, Yuan-Han Qin
Apr 22, 2015·Plant Molecular Biology·Janusz PiechotaHanna Jańska
May 2, 2014·Frontiers in Plant Science·Bernadette Gehl, Lee J Sweetlove
Feb 26, 2009·FEMS Microbiology Letters·Huey-Wen ChuangYueh-Long Chang
Feb 24, 2011·Journal of Proteome Research·Tiago S BalbuenaJay J Thelen
Jul 30, 2016·The Plant Journal : for Cell and Molecular Biology·Rosa M Lopez-CobolloColin G N Turnbull
Nov 5, 2016·Clinical and Experimental Nephrology·Keisuke SugimotoTsukasa Takemura
Nov 7, 2016·Journal of Experimental Botany·Judith Van DingenenDirk Inzé
Mar 27, 2018·The Plant Journal : for Cell and Molecular Biology·Martina JokelYagut Allahverdiyeva
Aug 21, 2019·Plant Signaling & Behavior·Ruihua HuangShengchun Zhang
Nov 30, 2018·Frontiers in Plant Science·Sridharan JegadeesanNurit Firon
Aug 20, 2019·Cellular and Molecular Life Sciences : CMLS·Meng YuJinxing Lin
Jul 6, 2013·Protein & Cell·Rasika VartakYidong Bai
Nov 8, 2020·Journal of Proteomics·Ana Luiza S PaivaMárcia Margis-Pinheiro

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