Proinflammation: the key to arterial aging

Trends in Endocrinology and Metabolism : TEM
Mingyi WangEdward G Lakatta

Abstract

Arterial aging is the major contributing factor to increases in the incidence and prevalence of cardiovascular disease, due mainly to the presence of chronic, low-grade, 'sterile' arterial inflammation. Inflammatory signaling driven by the angiotensin II cascade perpetrates adverse age-associated arterial structural and functional remodeling. The aged artery is characterized by endothelial disruption, enhanced vascular smooth muscle cell (VMSC) migration and proliferation, extracellular matrix (ECM) deposition, elastin fracture, and matrix calcification/amyloidosis/glycation. Importantly, the molecular mechanisms of arterial aging are also relevant to the pathogenesis of hypertension and atherosclerosis. Age-associated arterial proinflammation is to some extent mutable, and interventions to suppress or delay it may have the potential to ameliorate or retard age-associated arterial diseases.

References

Jul 21, 1999·Proceedings of the National Academy of Sciences of the United States of America·B HäggqvistP Westermark
Nov 13, 1999·Circulation Research·C Fernandez-PatronS T Davidge
Jun 10, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·K AsaiS F Vatner
Dec 20, 2000·The Journal of Experimental Medicine·B van der LooT F Lüscher
Feb 7, 2001·Proceedings of the National Academy of Sciences of the United States of America·P V VaitkeviciusE G Lakatta
Apr 23, 2002·Hypertension·Mingyi Wang, Edward G Lakatta
May 14, 2003·Hypertension·Mingyi WangEdward G Lakatta
Jun 5, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Gaia SpinettiEdward G Lakatta
Sep 3, 2005·The Journal of Clinical Investigation·Yumei ZhanPeter Oettgen
Nov 7, 2006·Nature·Joseph A BaurDavid A Sinclair
Apr 25, 2007·Hypertension·Mingyi WangEdward G Lakatta
Jun 15, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Nidia BassoFelipe Inserra
Jan 19, 2008·Circulation Research·Kristen A JohnsonRobert A Terkeltaub
Apr 19, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Ryohei MiyazakiKenji Sunagawa
Jul 5, 2008·Journal of Applied Physiology·Anna CsiszarZoltan Ungvari
Oct 31, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hideyuki EtoChuwa Tei
May 12, 2009·The Medical Clinics of North America·Edward G LakattaSamer S Najjar
Oct 27, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Sheik J KhanRoberto I Vazquez-Padron
Dec 19, 2009·Circulation·UNKNOWN WRITING GROUP MEMBERSUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Dec 31, 2009·Current Opinion in Nephrology and Hypertension·Mingyi WangEdward G Lakatta
Jan 19, 2010·Journal of Molecular and Cellular Cardiology·Mingyi WangAjay M Shah
Feb 24, 2010·Circulation·Donald Lloyd-JonesUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Apr 27, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Zoltan UngvariAnna Csiszar
Mar 23, 2011·Current Hypertension Reviews·Mingyi WangEdward G Lakatta
May 31, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Lisa A LesniewskiDouglas R Seals
May 31, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Zoltan UngvariAnna Csiszar
Jul 9, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Sei-ichiro MotegiMark C Udey
Jul 13, 2011·The Journal of Physiology·Anthony J DonatoDouglas R Seals

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Citations

Apr 26, 2014·Current Opinion in Immunology·Graham PawelecEvelyna Derhovanessian
Feb 18, 2016·Journal of Assisted Reproduction and Genetics·Zaher MerhiErkan Buyuk
Jan 21, 2016·Expert Opinion on Therapeutic Targets·Lucie HénautAlberto Ortiz
Sep 4, 2015·Biogerontology·Jonathan A BrassardCorinne A Hoesli
Feb 11, 2015·Journal of Molecular and Cellular Cardiology·Mingyi Wang, Ajay M Shah
Apr 15, 2015·Journal of Molecular and Cellular Cardiology·Edward G Lakatta
Mar 15, 2016·Experimental Gerontology·P BambrickJ Cooke
Oct 30, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ileana BadiAngela Raucci
Jun 17, 2015·Journal of Immunological Methods·Anders LarssonMasood Kamali-Moghaddam
Dec 4, 2015·Methodist DeBakey Cardiovascular Journal·Timo Z Nazari-Shafti, John P Cooke
Mar 17, 2015·Acta Psychiatrica Scandinavica·J D Rosenblat, R S McIntyre
Sep 1, 2015·Frontiers in Physiology·Guanghong JiaJames R Sowers
Jun 23, 2015·Pharmacology & Therapeutics·Serge AdnotJorge Boczkowski
Apr 22, 2015·Neurodegenerative Disease Management·Timothy M HughesOscar L Lopez
Apr 28, 2016·The Canadian Journal of Cardiology·Matthias BartonMatthias R Meyer
Mar 25, 2016·Cardiovascular Research·Laurent DucaPascal Maurice
Oct 22, 2016·Ageing Research Reviews·Thomas J LaRoccaDouglas R Seals
Apr 18, 2014·European Heart Journal·Peter LanzerCatherine Shanahan
Jan 28, 2017·Tissue Engineering. Part a·Aref ShahiniStelios T Andreadis
Mar 23, 2017·Journal of Cardiovascular Pharmacology·Nicholas A Flavahan
Dec 10, 2015·The Journal of Physiology·Simona GargiuloGiuseppe Poli
Jan 6, 2018·Frontiers in Physiology·Ying ZhouLiang Yin
Jun 8, 2017·World Journal of Biological Chemistry·Ken-Ichi IsobeTadao Hasegawa
Nov 4, 2017·The Journal of International Medical Research·Maki KomiyamaKoji Hasegawa
Feb 25, 2018·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Mario Fritsch NevesWille Oigman
Aug 2, 2018·Nature Reviews. Cardiology·Edward G Lakatta
Jun 13, 2018·Hypertension·Bradley S FleenorCraig A Emter
Jul 15, 2015·Hypertension·Raymond R TownsendUNKNOWN American Heart Association Council on Hypertension
May 14, 2016·Circulation Research·Hiroyuki NakayamaKinya Otsu
Dec 15, 2015·Journal of Cardiovascular Pharmacology·Yumeng GuoYu Wang
Jul 17, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Sheila FlavahanNicholas A Flavahan
Oct 28, 2017·Journal of Applied Physiology·Rachel A Gioscia-RyanDouglas R Seals

❮ Previous
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