Proinflammatory cytokine levels in oral lichen planus, oral leukoplakia, and oral submucous fibrosis

Journal of the Korean Association of Oral and Maxillofacial Surgeons
Jasdeep Kaur, Reinhilde Jacobs

Abstract

The objective of this study was to identify salivary and serum concentrations of interleukin (IL)-8, IL-6, and tumor necrosis factor alpha (TNF-α) in patients with oral lichen planus, oral leukoplakia, oral submucous fibrosis, and healthy controls. Patients selected included 54 oral lichen planus (41 to 65 years), 50 oral leukoplakia (42 to 65 years), 51 oral submucous fibrosis (41 to 65 years), and 50 healthy controls (42 to 65 years). Oral lichen planus, oral leukoplakia, and oral submucous fibrosis cases were diagnosed using histopathological analysis. Salivary and serum cytokine concentrations were measured using enzyme-linked immunoassay kits in all subjects. The levels of serum and salivary TNF-α, IL-6, and IL-8 were statistically significantly increased in oral leukoplakia, submucous fibrosis, and lichen planus in contrast to normal healthy subjects (P<0.05). Serum and salivary correlation analysis revealed strong and highly significant correlations for TNF-α, IL-6, and IL-8 in all groups (r=0.72-0.82, P<0.05). Salivary and serum cytokines were also elevated when analyzed in oral precancerous lesions. Thus, salivary and serum IL-8, IL-6, and TNF-α levels might act as diagnostic markers for detection of oral precancer.

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Citations

Apr 12, 2017·Diagnostics·Haafsa Arshad SahibzadaMuhammad Sohail Zafar
May 11, 2018·Clinical and Experimental Dental Research·Kristine Roen LarsenAnne Marie Lynge Pedersen
Jul 24, 2018·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Mei-Yin YeYuh-Ling Chen
Oct 18, 2018·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Jun ShenGuangbao Song
Jan 10, 2019·Journal of Cellular Physiology·Tzer-Min KuoYing-Chin Ko
Feb 7, 2020·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·John AdeoyePeter Thomson
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May 29, 2018·Experimental and Therapeutic Medicine·Zhi-Rui ZhangShao-Hua Sun
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Apr 5, 2021·Clinical Oral Investigations·Shalini R GuptaKalaivani Mani

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Methods Mentioned

BETA
enzyme-linked immunoassay
ELISA

Software Mentioned

SPSS

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