Proinflammatory cytokine polymorphisms and the risk of preterm birth and low birthweight in a Japanese population

Molecular Human Reproduction
F SataR Kishi

Abstract

Pregnancy and parturition involve a complex and poorly understood molecular and biological interplay between mother and fetus. Inflammatory cytokines have been reported to be associated with fetal growth and parturition. The aim of this study was to examine whether common proinflammatory cytokine polymorphisms are associated with preterm birth (PTB), low birthweight or intrauterine growth restriction in a Japanese population. We assessed a consecutive series of 414 women who had singleton deliveries in Sapporo, Japan between 2001 and 2005. Genotyping of IL1A -889C/T, +4845G/T (A114S), IL1B -511C/T, -31C/T, IL2 -384T/G and IL6 -634C/G polymorphisms was determined by an allelic discrimination assay. The risk of PTB significantly increased in women carrying the IL1A -889T allele (CC genotype [reference]; CT genotype, odds ratios (OR): 2.5; 95% confidence intervals (95% CI): 1.4-4.8; CT+TT genotypes [dominant genotype model], OR: 2.5, 95% CI: 1.3-4.6). Similarly, the risk of PTB significantly increased in women carrying the IL1A +4845T allele (GG genotype [reference]; GT genotype, OR: 2.4, 95% CI: 1.3-4.4; GT+TT genotypes [dominant genotype model], OR: 2.3, 95% CI: 1.2-4.2). The frequency of the IL1A TT haplotype in mothers with PT...Continue Reading

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Citations

Jun 21, 2011·DNA and Cell Biology·Yaprak YılmazFatma Belgin Atac
Nov 1, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·Mathieu Nadeau-ValléeSylvie Girard
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Nov 18, 2017·Indian Journal of Pediatrics·Monika PandeyAbbas Ali Mahdi
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May 21, 2021·Clinical Genetics·Joana CouceiroAlexandre Quintas
Aug 3, 2010·American Journal of Obstetrics and Gynecology·Roberto RomeroRamkumar Menon

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