Proinflammatory cytokine production by human peripheral blood mononuclear cells stimulated with cell-free supernatants of Viridans streptococci

Cytokine
A SotoJ Cohen

Abstract

Viridans streptococci (VS) have become recognized as an increasingly important cause of bacteraemia in neutropenic patients undergoing chemotherapy. Surprisingly, VS bacteraemia is associated with toxic shock-like syndrome (TSLS) and adult respiratory distress syndrome (ARDS), features not seen in non-neutropenic patients with viridans streptococcal bacteraemia. The mechanism by which these Gram-positive bacteria cause hypo-tension in the absence of endotoxin is not known. In this study, we have analysed the ability of cell-free bacterial supernatants derived from VS to induce the production of a number of cytokines from human peripheral blood mononuclear cells (PBMC). These cytokines were tumour necrosis factor alpha (TNF-alpha), tumour necrosis factor beta (TNF-beta) and interleukin 8 (IL-8). All 59 strains were able to induce these proinflammatory cytokines. We conclude that VS do produce secreted products which are able to stimulate the production of cytokines which may be important in the pathogenesis of shock caused by these bacteria.

Citations

Dec 10, 1999·The Annals of Thoracic Surgery·S B HortonT R Karl
Aug 2, 2000·Proceedings of the National Academy of Sciences of the United States of America·R E Hancock, M G Scott
Jan 27, 2007·BMC Bioinformatics·Manisha BrahmacharyVladimir B Bajic
May 23, 2014·PloS One·Kevin J WoollardJaye P F Chin-Dusting
Aug 27, 2009·PloS One·Raquel M RaicesMark D Wewers
Jun 21, 2019·Biological & Pharmaceutical Bulletin·Yiping ZhuAie Xu
Jun 10, 2015·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Ashley D FranklinZhengguo Xiao
Nov 24, 1999·Infection and Immunity·M G ScottR E Hancock

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