Proinflammatory cytokines and cardio-vascular risk: From myocardial infarction tocytokine storm of COVID-19

Bulletin de l'Académie nationale de médecine
Pierre Miossec

Abstract

The mechanisms of inflammatory diseases involve the key inflammatory cytokines IL-1, TNF, IL-6, and IL-17 which are now therapeutic targets with biotherapies. They contribute to the local manifestations of clinically different diseases. In addition to these local aspects, these cytokines have systemic effects from their action on the liver, muscle, adipose tissue and the cardiovascular system. All these diseases have in common an increase in cardiovascular risk. In the general population, the same concepts are applicable, as shown by the link between an even modest rise in CRP and cardiovascular risk. More recently, the cytokine storm of severe forms of COVID-19 has shown that synergistic interactions between cytokines first described in vitro are further amplified in the clinical picture with multiple and severe impairment of key organs. In these chronic and acute contexts, control of inflammation by targeting cytokines is a new vascular treatment option, with already important results for IL-1.

References

Mar 13, 2001·Annual Review of Immunology·M Feldmann, R N Maini
Mar 31, 2004·The American Journal of Medicine·Peter Libby, Paul M Ridker
Aug 28, 2009·The New England Journal of Medicine·Pierre MiossecVijay K Kuchroo
Apr 23, 2010·International Immunology·Tadamitsu Kishimoto
May 20, 2011·Nature·Peter LibbyGöran K Hansson
Feb 4, 2016·Trends in Molecular Medicine·Audrey BeringerPierre Miossec
Dec 16, 2016·PLoS Pathogens·Jeroen SlaatsMihai G Netea
Jan 12, 2017·Annals of the Rheumatic Diseases·Audrey S L LowUNKNOWN British Society for Rheumatology Biologics Register for Rheumatoid Arthritis (BSRBR-RA) and the BSRBR Control Centre Consort
Feb 19, 2017·Seminars in Immunopathology·Mélissa Noack, Pierre Miossec
Jul 15, 2017·Autoimmunity Reviews·Marie Robert, Pierre Miossec
Aug 29, 2017·The New England Journal of Medicine·Paul M RidkerUNKNOWN CANTOS Trial Group
Jan 11, 2020·Frontiers in Cardiovascular Medicine·Pietro Enea LazzeriniPier Leopoldo Capecchi
Feb 23, 2020·Proceedings of the National Academy of Sciences of the United States of America·Kamil SlowikowskiSoumya Raychaudhuri
Mar 21, 2020·Lancet·Puja MehtaUNKNOWN HLH Across Speciality Collaboration, UK
Apr 14, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Zhenyu FanJilin Cheng
Apr 24, 2020·Lancet·Zsuzsanna VargaHolger Moch
Apr 30, 2020·The New England Journal of Medicine·Enrico BaldiUNKNOWN Lombardia CARe Researchers

❮ Previous
Next ❯

Software Mentioned

CANTOS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Human Vaccines & Immunotherapeutics
Mohsen RokniNima Rezaei
Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
Krishna Kant GuptaSanjeev Kumar Singh
© 2021 Meta ULC. All rights reserved