Proinflammatory cytokines and their membrane-bound receptors are altered in the lymphocytes of schizophrenia patients

Schizophrenia Research
Ghanshyam N PandeyHui Zhang

Abstract

Abnormalities of protein levels of proinflammatory cytokines and their soluble receptors have been reported in the plasma/serum of schizophrenia (SZ) patients. To examine if SZ is also associated with the abnormal gene expression of cytokines and their membrane-bound receptors, we studied mRNA expression of proinflammatory cytokines and their receptors in lymphocytes of SZ patients and normal control (NC) subjects. We determined the protein and mRNA expression of proinflammatory cytokines and mRNA expression of their receptors in lymphocytes from 30 SZ patients and 30 drug-free NC subjects. The subjects were diagnosed according to DSM-IV criteria. Protein levels of cytokines were determined by ELISA, and mRNA levels in lymphocytes were determined by the qPCR method. We found that the mRNA levels of IL-6, TNF-α, IL-1R1, TNFR1, and TNFR2, but not IL-1β, IL-1R2, IL-1RA, IL-6R, or GP130 were significantly increased in lymphocytes of SZ patients compared with NC subjects. We also found that the protein expression of IL-6 and TNF-α, but not IL-1β, was also significantly increased in SZ patients compared with NC subjects. These studies suggest that in addition to the reported abnormalities of proinflammatory cytokines and their solubl...Continue Reading

References

Jan 1, 1992·Immunologic Research·J RotheW Lesslauer
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J E SimsS K Dower
Jan 1, 1995·Progress in Neuro-psychopharmacology & Biological Psychiatry·M Maes
Apr 4, 2006·Brain, Behavior, and Immunity·Lukasz DrzyzgaZbigniew S Herman
May 19, 2006·Journal of Leukocyte Biology·Stefan Rose-JohnSimon A Jones
Nov 17, 2007·Biological Psychiatry·Stéphane PotvinEdouard Kouassi
Dec 22, 2009·Expert Review of Neurotherapeutics·Roosmarijn C DrexhageHemmo A Drexhage
Jun 7, 2011·Biological Psychiatry·Brian J MillerBrian Kirkpatrick
Jul 4, 2012·Journal of Affective Disorders·Klaus MunkholmLars Vedel Kessing
Nov 6, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Kyoung-Sae NaYong-Ku Kim
Feb 19, 2013·Biological Psychiatry·Anna M Fineberg, Lauren M Ellman
Feb 20, 2013·Biological Psychiatry·Amirhossein ModabberniaMandana Ashrafi
Jun 19, 2013·Journal of Psychiatric Research·Klaus MunkholmMaj Vinberg
Sep 18, 2013·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Roksana Zakharyan, Anna Boyajyan
Jan 21, 2014·Biological Psychiatry·Ragy R GirgisAlan S Brown

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Citations

Nov 5, 2016·Physiology & Behavior·Caroline LavrattiViviane Rostirola Elsner
Dec 17, 2017·Immunological Reviews·Diana BoraschiMichael U Martin
Jun 19, 2019·Human Molecular Genetics·Veronica L HoodAmanda J Law
Sep 27, 2018·Mediators of Inflammation·Renata Suchanek-RaifJan Kowalski
Jun 14, 2020·International Journal of Molecular Sciences·Mary Jasmin AngChangjong Moon
Jan 5, 2017·Schizophrenia Bulletin·Eva Zsuzsanna HosethOle Andreas Andreassen
Oct 16, 2021·Translational Psychiatry·Caitlin E MurphyCynthia Shannon Weickert

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