PMID: 11931491Apr 5, 2002Paper

Proinflammatory cytokines are not released in the circulation following acute pulmonary thromboembolism in pigs

Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research
John Y C TsangBruno Battistini

Abstract

Histological examination of acute lung injury associated with sepsis often revealed thromboembolic lesions in the pulmonary microcirculation. Several inflammatory mediators such as platelet activating factor, thromboxane, and endothelins have also been implicated in the pathogenesis of acute pulmonary thromboembolism (APTE). In the present study we examined the roles of three proinflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha), interleukin 1beta (IL-1beta), and IL-8, in the early phase of APTE. APTE was induced in 13 anesthetized piglets (22+/-4 kg) by injecting thrombin-induced blood clots directly into the left lower lobar pulmonary artery. Five animals that received only warm sterile saline served as controls. Arterial plasma samples were collected regularly over 8 h so that cytokine levels could be measured later by enzyme-linked immunosorbent assay (ELISA). Administration of clots doubled the mean pulmonary arterial pressure (from 13+/-5 to 26+/-7 mm Hg) and caused significant decrease in arterial oxygen tension (PaO2 from 390+/-85 to 256+/-89 mm Hg while the FiO2 was maintained at 1.0). Mean arterial blood pressure and cardiac output remained comparable throughout the experiments after initial fluid resusci...Continue Reading

Citations

Dec 14, 2004·Journal of Applied Physiology·John Y C TsangMichael P Hlastala
Sep 19, 2006·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·D MutschlerM Eriksson
Jul 4, 2003·Canadian Journal of Physiology and Pharmacology·Bruno Battistini

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