Proinflammatory cytokines in cerebrospinal fluid and serum in patients with disc herniation and sciatica

European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
H BrisbyB Rydevik

Abstract

Proinflammatory cytokines have been identified in herniated intervertebral discs in humans, and such cytokines have experimentally been demonstrated to be important in the pathophysiological mechanisms of disc herniation. Cerebrospinal fluid (CSF) and serum concentrations of interleukin (IL)-1beta IL-6, IL-8, interferon (IFN)-gamma and tumour necrosis factor (TNF)-alpha were investigated using the enzyme-linked immunosorbent assay (ELISA) technique in 39 patients with lumbar disc herniation and sciatica. Pain duration and pain intensity (visual analogue scale, VAS) were recorded at inclusion, and a clinical examination was performed evaluating neurological findings. The extent of disc herniation (protrusion or extrusion/sequestration) was evaluated perioperatively. Normal concentrations of IL-1beta, IL-6, IFN-gamma and TNF-alpha were present in CSF and serum in almost all patients with lumbar disc herniation. The concentrations of IL-8 in CSF were increased in 12 out of 39 patients, and these increased levels of IL-8 correlated to a short duration of pain and to more pronounced herniation (extrusion or sequestration). No relationship between IL-8 concentrations in CSF and pain intensity, positive neurological findings or a posi...Continue Reading

Citations

Aug 9, 2003·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Anders LundinLars Samuelsson
May 13, 2004·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Peter FritzellChristina Welinder-Olsson
Nov 15, 2006·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Markus QuanteJürgen Lorenz
May 4, 2007·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Mehmet Nusret DemircanHakan Simsek
Jun 23, 2009·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Hideki NagashimaRyota Teshima
May 22, 2010·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Hideki NagashimaRyota Teshima
Oct 19, 2010·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Seiji OhtoriKazuhisa Takahashi
Sep 18, 2008·Current Pain and Headache Reports·Nurcan Uçeyler, Claudia Sommer
Nov 10, 2004·Spine·Michael CornefjordHelena Brisby
Sep 24, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Cielito C Reyes-GibbySanjay Shete
Jul 23, 2009·Clinical Drug Investigation·Antonio MarchiGabriele Finco
Nov 23, 2006·AJR. American Journal of Roentgenology·Joon Woo LeeHeung Sik Kang
Jul 1, 2012·Pain Management·Nurcan Uçeyler, Claudia Sommer
May 5, 2011·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Ali Ghahreman, Nikolai Bogduk
Sep 3, 2013·Expert Opinion on Therapeutic Targets·Alberto Di MartinoCesare Faldini
Nov 14, 2007·Expert Review of Neurotherapeutics·Maria Schäfers, Claudia Sommer
Oct 30, 2014·Pain Practice : the Official Journal of World Institute of Pain·Martin F BjurstromCharles A Griffis
Aug 14, 2010·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Ali GhahremanNikolai Bogduk
Apr 3, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Sarah M RauschPing Yang
Jul 8, 2011·PM & R : the Journal of Injury, Function, and Rehabilitation·Wan Huang, Gwendolyn Sowa
Aug 30, 2012·Pain Management Nursing : Official Journal of the American Society of Pain Management Nurses·Mamoona Arif-RahuYui Matsuda
Mar 9, 2010·The Spine Journal : Official Journal of the North American Spine Society·Jason M CuellarGaetano J Scuderi
Jul 25, 2009·PM & R : the Journal of Injury, Function, and Rehabilitation·Scott T RobertsJoshua D Rittenberg
Aug 2, 2008·The Lancet Oncology·Cielito C Reyes-GibbySanjay Shete
Jun 13, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mohammed F ShamjiLori A Setton
Apr 12, 2008·Neuroscience Letters·Nurcan Uçeyler, Claudia Sommer
Mar 8, 2008·Journal of Neuroimmunology·Miroslav Misha BackonjaKathleen Schell
Dec 11, 2007·The Spine Journal : Official Journal of the North American Spine Society·Gaetano J ScuderiAlexander R Vaccaro
Mar 7, 2008·European Journal of Pain : EJP·Jaro KarppinenMinna Männikkö
Mar 24, 2007·Acta Anaesthesiologica Scandinavica·T InadaK Shingu

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