Proinflammatory cytokines: measurement in nasal secretion and induction of adhesion receptor expression

International Archives of Allergy and Immunology
C BachertU Hauser

Abstract

We recently demonstrated that interleukin (IL)-1 beta, tumor necrosis factor (TNF)-alpha, IL-6 and IL-8 can be found in nasal secretions from allergic rhinitis patients under artificial and natural conditions. By ELISA measurements, significantly elevated baseline levels for IL-1 beta, IL-6 and IL-8 were found in seasonal allergic compared to control subjects. Within the first 2 h after nasal allergen challenge, IL-1 beta and TNF are secreted, whereas IL-6 and IL-8 showed a slow increase over 6-8 h. All cytokine levels returned to baseline within 24 h after exposure. Repeated measurements at 4-week intervals in perennial allergic rhinitis subjects (n = 27) showed significant correlations between IL-1 and IL-8, IL-6 and IL-8 and IL-6 and the symptom score (visual analogue scale). The IL-1 receptor antagonist IL-1ra was found in great molar excess in the secretions and correlated significantly with IL-8, but not IL-1 beta. In an in vitro assay using fresh nasal mucosa of grass-pollen-allergic subjects, we were able to demonstrate a strong and rapid induction of E-selectin adhesion receptor expression on endothelial cells by allergen, IL-1 beta and TNF. The adhesion receptor expression was markedly inhibited by soluble IL-1 recept...Continue Reading

Citations

Oct 10, 2003·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Veli-Pekka Joki-ErkkiläMikko Hurme
Aug 10, 2002·Allergy·B VerhaegheC Bachert
Nov 24, 1999·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·M BensonO Strannegård
Mar 22, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M BensonL O Cardell
Aug 17, 2001·Journal of Immunoassay & Immunochemistry·E J Pool, P Bouic
Mar 10, 1998·Allergy·C BachertP van Cauwenberge
Feb 14, 2009·American Journal of Respiratory Cell and Molecular Biology·Cecilia EstrellaPhilippe Gosset
Feb 13, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C Bachert
Jan 1, 1997·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·T HimiA Kataura
Dec 14, 2004·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Stephen LoAndrew W McCombe
Apr 30, 2013·Expert Opinion on Biological Therapy·Priyanka Vashisht, Thomas Casale
Sep 29, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Daniel BaumannPetra Högger
Jun 23, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D BaumannP Högger
Mar 10, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A NietersN Becker
Jan 8, 2009·Headache·Srikanth DamodaramPaul L Durham
Mar 16, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R TakizawaT Yagi
Mar 26, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C ShenC Pilette
Mar 30, 1999·Acta Oto-laryngologica. Supplementum·H KawamotoK Yajin
Jul 26, 2013·American Journal of Rhinology & Allergy·Ina CallebautPeter W Hellings
Aug 1, 1997·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·M BensonO Strannegård
Jul 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Victor J JohnsonMichael I Luster
Apr 12, 2016·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S Gilles-SteinC Traidl-Hoffmann
Sep 28, 2016·International Forum of Allergy & Rhinology·Davi Sousa GarciaAndrew P Lane
Dec 13, 2019·Oxidative Medicine and Cellular Longevity·Ahmed Adel SadekMahmoud Zaki El-Readi
Mar 26, 1998·American Journal of Rhinology·C BachertG Holtappels
Nov 15, 2001·The Journal of Allergy and Clinical Immunology·J BousquetUNKNOWN World Health Organization

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