Proinflammatory cytokines regulate epidermal stem cells in wound epithelialization.

Stem Cell Research & Therapy
Tong XiaoYumin Xia

Abstract

The skin, which serves as the first barrier of the human body, is particularly susceptible to exogenous injuries. Skin wounds, including acute burns and chronic non-healing ulcers, are commonly observed in clinics. Healing of skin wounds is a complex process, consisting of infiltration of inflammatory cells, cellular proliferation, and tissue remodeling phases, which restore the integrity and functions of the skin. Epithelialization is involved in wound healing through re-establishing an intact keratinocyte layer. Epidermal stem cells are indispensable for epithelialization, and they are regulated by multiple proinflammatory cytokines or growth factors. In this review, we summarize recent advances in the effect of these cytokines on migration, proliferation, and differentiation processes of epidermal stem cells. We also introduce promising therapeutic strategies targeting epidermal stem cells or related proinflammatory cytokines for patients with skin wounds.

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Citations

Feb 14, 2021·Drug Delivery and Translational Research·Poonam MalhotraSiddharth Pandey
Mar 7, 2021·International Journal of Molecular Sciences·Paula O CooperBrett A Shook
May 18, 2021·3 Biotech·Amita AjitPrashanth Varkey
Aug 20, 2021·Mechanisms of Ageing and Development·Tanya PulidoFatouma Alimirah
Jan 29, 2022·Molecular and Cellular Biochemistry·Vikrant RaiDevendra K Agrawal

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