Proinflammatory gene expression in patients undergoing mitral valve surgery and maze ablation for atrial fibrillation

The Journal of Thoracic and Cardiovascular Surgery
Feng-Chun TsaiYung-Hsin Yeh

Abstract

It is difficult to achieve rhythm control in patients with long-standing persistent atrial fibrillation (AF). The radiofrequency maze procedure is an effective means in curing AF with a variable recurrence rate depending on patient characteristics and AF duration. In these patients, the characteristics of the atrial substrate have not been well investigated. Because the inflammatory process has been shown to be important in the pathogenesis of AF, we sought to characterize the proinflammatory gene expression in left atria obtained from patients with AF undergoing mitral valve surgery combined with the maze procedure to distinguish the changes associated with AF and its recurrence after the surgical ablation. Left atrial appendages from 35 patients receiving mitral valve surgery were used for study. Ten patients had sinus rhythm (SR) and 25 patients had persistent AF for more than 1 year and underwent the maze procedure. Among the AF patients, 13 patients remained in SR (AF-SR) and 12 patients had recurrent AF during the 1-year clinical follow-up (AF-AF). The nCounter Human Inflammation Array (NanoString Technologies, Seattle, Wash) was used for evaluating proinflammatory gene expression. Quantitative polymerase chain reaction, ...Continue Reading

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Citations

Mar 20, 2016·The Journal of Thoracic and Cardiovascular Surgery·Rupak Mukherjee
Sep 29, 2019·Cardiovascular Diabetology·Yi-Hsin ChanYung-Hsin Yeh
Oct 2, 2019·Experimental and Therapeutic Medicine·Irfan V DüzenAbdullah T Demiryürek

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