Proinflammatory mediator expression in a novel murine model of titanium-particle-induced intramedullary inflammation

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Bryan A WarmeR Lane Smith

Abstract

Wear debris from total joint replacement prostheses is implicated in periprosthetic osteolysis and implant loosening. The pathophysiology of this biological process remains unclear. Animal models of particle-induced osteolysis have proven useful in the study of specific tissue responses to wear debris. However, existing in vivo murine models of particle-mediated inflammation do not permit analysis of cortical bone degradation. This study describes a murine model of particle disease using an intramedullary rod in the mouse femur to parallel the clinical situation. The model consists of placing a 10-mm-long Kirschner wire retrograde in both femurs of C57b1/6 male mice via a medial parapatellar arthrotomy. Phagocytosable titanium particles were also implanted unilaterally to replicate generation of wear debris. Mice were sacrificed at 2, 10, and 26 weeks and whole femurs were cultured for 72 h. Levels of interleukin-6, monocyte chemotactic protein-1, and macrophage colony stimulating factor were assayed by ELISA. Transverse histological sections, at the level of the implant, were taken and stained with hematoxylin and eosin (H&E). Results demonstrated increased expression of proinflammatory mediators at 2 weeks in femora with rod ...Continue Reading

References

Jan 1, 1995·Journal of Applied Biomaterials : an Official Journal of the Society for Biomaterials·W J KraemerJ F Zhao
Jan 23, 1999·The American Journal of Pathology·K D MerkelS L Teitelbaum
Jul 27, 1999·Journal of Biomedical Materials Research·M C TrindadeS B Goodman
Jan 13, 2000·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·A A RagabE M Greenfield
May 9, 2001·The Journal of Bone and Joint Surgery. British Volume·L C JonesD S Hungerford
Jan 5, 2002·Biomaterials·Paul H WooleySam Nasser
Feb 28, 2002·The Journal of Bone and Joint Surgery. American Volume·Peter J MillettMathias P G Bostrom
Jun 1, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Elizabeth A FritzKenneth A Roebuck
Jun 1, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Miho IwaseTatsuo Itoh
Jun 13, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Subhra K Biswas, Ajit Sodhi
Oct 18, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Weiping RenPaul H Wooley
Dec 11, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Masakazu YoshidaAkihiro Matsukawa

❮ Previous
Next ❯

Citations

Nov 12, 2010·International Orthopaedics·Jean Langlois, Moussa Hamadouche
Oct 7, 2006·Der Pathologe·M OttoS Bertz
Aug 30, 2008·HSS Journal : the Musculoskeletal Journal of Hospital for Special Surgery·P Edward PurdueThomas P Sculco
Jan 16, 2014·HSS Journal : the Musculoskeletal Journal of Hospital for Special Surgery·P Edward PurdueSteven R Goldring
May 25, 2012·Science Translational Medicine·Aránzazu MedieroBruce N Cronstein
Dec 12, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ke RenDong Wang
Sep 26, 2015·International Journal of Molecular Sciences·Weiwei LouGang Wu
May 27, 2008·Nanomedicine : Nanotechnology, Biology, and Medicine·Paul ThevenotLiping Tang
Dec 19, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·S ZilberS B Goodman
Sep 9, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Ting MaStuart B Goodman
Jun 7, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Steven G OrtizStuart B Goodman
Jun 24, 2006·Biomaterials·Gema VallésNuria Vilaboa
Nov 2, 2011·Acta Biomaterialia·Shaylin Shadanbaz, George J Dias
Jun 22, 2016·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Emmanuel GibonStuart B Goodman
Dec 30, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·J PajarinenS B Goodman
May 27, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Meghan M MoranDale Rick Sumner
Oct 24, 2012·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Shaylin ShadanbazAlexis Pietak
Sep 9, 2017·Critical Reviews in Biotechnology·Julien BarthesNihal Engin Vrana
Sep 19, 2006·Clinical Orthopaedics and Related Research·P Edward PurdueThomas P Sculco
Jun 28, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Steven G OrtizStuart B Goodman
Jun 28, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Jin-Woo ParkJo-Young Suh
Jun 15, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Sébastien ZilberStuart B Goodman
Jul 10, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Bill BraggR Lane Smith
Aug 31, 2007·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Panagiotis KoulouvarisP Edward Purdue
Feb 6, 2007·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Shang-You YangPaul H Wooley
Mar 28, 2008·Autoimmunity·P Edward Purdue
Dec 2, 2011·Clinical Orthopaedics and Related Research·Vinod DasaWilliam M Mihalko
Apr 20, 2014·Journal of Applied Biomaterials & Functional Materials·Maurizio SabbatiniMario Cannas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Noah J EpsteinStuart B Goodman
Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Naoya TakiEdward M Greenfield
Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Shang-You YangP H Wooley
Proceedings of the National Academy of Sciences of the United States of America
Moon G ChoiK-L Paul Sung
© 2021 Meta ULC. All rights reserved