Abstract
Gestational diabetes mellitus (GDM) is a common metabolic disorder occurring in up to 10% of pregnancies in the western world. Most women with GDM are asymptomatic; therefore, it is important to screen, diagnose and manage the condition as it is associated with an increased risk of maternal and perinatal complications. Diagnosis of GDM is made in the late second trimester or early third trimester because accurate diagnosis or risk stratification in the first trimester is still lacking. An increase in serum proinsulin may be seen earlier in pregnancy and before a change in glycaemic control can be identified. This study will aim to establish if fasting proinsulin concentrations at 16-18 weeks gestation will help to identify or risk stratify high-risk pregnant women with GDM. This is a prospective, longitudinal cohort study. Two oral glucose tolerance tests will be carried out at 16-18 and 24-28 weeks gestation in 200 pregnant women with at least one risk factor for GDM (body mass index>30 kg/m2, previous macrosomic baby (>4.5 kg), previous gestational diabetes, first degree relative with type 2 diabetes mellitus) recruited from antenatal clinics. Blood samples will be taken fasting and at 30 min, 1 and 2 hours following the 75 g...Continue Reading
References
Dec 1, 1975·The Journal of Clinical Endocrinology and Metabolism·R L PhelpsM Mako
Mar 1, 1991·Clinical Endocrinology·A DornhorstD G Johnston
Sep 1, 1987·Diabetologia·W K WardD Porte
Aug 1, 1995·Diabetes·R A SwinnS O'Rahilly
Dec 1, 1993·Diabetes Care·B E MetzgerR Radvany
Sep 1, 1996·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·N M Buderer
Apr 1, 1997·Diabetes·A Kautzky-WillerR Prager
Nov 28, 2002·BJOG : an International Journal of Obstetrics and Gynaecology·Yvonne LinnéStephan Rössner
Jul 17, 2008·Diabetes Care·Ravi RetnakaranBernard Zinman
May 26, 2009·Lancet·Leanne BellamyDavid Williams
Oct 28, 2016·Midwifery·Pei-Chao Lin Ya-Ling Tzeng
Oct 18, 2016·Eating and Weight Disorders : EWD·Reihaneh PirjaniMahboubeh Hemmatabadi
Dec 9, 2016·PloS One·Sara L WhiteUNKNOWN UPBEAT Consortium
Feb 1, 2017·BMJ Open·Jérémie F CohenPatrick M M Bossuyt
Sep 18, 2017·Diabetes Research and Clinical Practice·David BenaigesAntonio Payà
Oct 4, 2017·Current Diabetes Reports·Jincy Immanuel, David Simmons