Projection-Resolved OCT Angiography of Microvascular Changes in Paracentral Acute Middle Maculopathy and Acute Macular Neuroretinopathy

Investigative Ophthalmology & Visual Science
Sally ChuAmani A Fawzi

Abstract

To identify the microvascular changes associated with paracentral acute middle maculopathy (PAMM) and acute macular neuroretinopathy (AMN) and to improve our understanding of the relevant involvement of the three retinal capillary plexuses using projection-resolved optical coherence tomography angiography (PR-OCTA). This was a retrospective study of 18 eyes with AMN or PAMM imaged with OCTA. We used cross-sectional PR-OCTA to localize reduced flow signal to the superficial (SCP), middle (MCP), or deep capillary plexus (DCP) or choriocapillaris that corresponded to inner retinal PAMM or outer retinal AMN lesions on OCT. Five eyes with AMN showed outer retinal disruption on OCT associated with reduced DCP flow signal. All three eyes with AMN and follow-up had recovery of DCP flow. Thirteen eyes with PAMM showed middle retinal disruption on OCT associated with reduced flow signal in both the MCP and DCP. Of these, five also had reduced flow signal in the SCP. All 10 eyes with PAMM and follow-up showed variable recovery of flow signal in one or more plexuses. PAMM reperfusion was primarily arterial in nature. Three eyes with PAMM and no evidence of MCP reperfusion experienced severe thinning of the inner nuclear layer (INL), while ...Continue Reading

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Citations

Aug 4, 2018·Investigative Ophthalmology & Visual Science·Peter L Nesper, Amani A Fawzi
Nov 22, 2018·Expert Review of Medical Devices·Malvika AryaNadia K Waheed
Dec 20, 2019·JAMA Ophthalmology·Prithvi RamtohulDaniè le Denis
Jan 22, 2020·Experimental Biology and Medicine·Xincheng YaoDevrim Toslak
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May 8, 2020·The British Journal of Ophthalmology·Caroline R BaumalK Bailey Freund
Jul 15, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Nuno Moura-CoelhoJoão Paulo Cunha
Aug 2, 2020·International Ophthalmology·Ramesh VenkateshNaresh Kumar Yadav
Apr 16, 2019·Therapeutic Advances in Ophthalmology·Alex C Onishi, Amani A Fawzi
Apr 12, 2019·Chinese Journal of Integrative Medicine·Jian-Guo WuWan-Yu Zhou
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Jan 17, 2021·Photodiagnosis and Photodynamic Therapy·Limin LiuRui Hua
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Software Mentioned

OCTA
PR

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