Projection specificity in heterogeneous locus coeruleus cell populations: implications for learning and memory

Learning & Memory
Akira UematsuJoshua P Johansen

Abstract

Noradrenergic neurons in the locus coeruleus (LC) play a critical role in many functions including learning and memory. This relatively small population of cells sends widespread projections throughout the brain including to a number of regions such as the amygdala which is involved in emotional associative learning and the medial prefrontal cortex which is important for facilitating flexibility when learning rules change. LC noradrenergic cells participate in both of these functions, but it is not clear how this small population of neurons modulates these partially distinct processes. Here we review anatomical, behavioral, and electrophysiological studies to assess how LC noradrenergic neurons regulate these different aspects of learning and memory. Previous work has demonstrated that subpopulations of LC noradrenergic cells innervate specific brain regions suggesting heterogeneity of function in LC neurons. Furthermore, noradrenaline in mPFC and amygdala has distinct effects on emotional learning and cognitive flexibility. Finally, neural recording data show that LC neurons respond during associative learning and when previously learned task contingencies change. Together, these studies suggest a working model in which distin...Continue Reading

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Citations

May 4, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Thomas F GiustinoStephen Maren
Sep 19, 2017·Nature Neuroscience·Akira UematsuJoshua P Johansen
Aug 30, 2017·Frontiers in Neuroanatomy·Maria Paola Tramonti FantozziDiego Manzoni
Sep 15, 2018·PloS One·Nozomu H NakamuraYoshitaka Oku
Sep 26, 2019·Nature Neuroscience·Ekaterina Likhtik, Joshua P Johansen
Aug 22, 2020·Psychopharmacology·Daniel LustbergDavid Weinshenker
Oct 21, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hillary C SchiffRobert M Sears
Nov 24, 2019·Molecular Psychiatry·Yiran GuRobert M Sears
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Sep 22, 2020·Brain and Neuroscience Advances·Laurel S MorrisJames W Murrough
Oct 28, 2019·Frontiers in Human Neuroscience·R L van den BrinkT H Donner
Sep 19, 2020·Nature Reviews. Neuroscience·Gina R PoeSusan J Sara
Mar 30, 2018·Frontiers in Behavioral Neuroscience·Thomas F Giustino, Stephen Maren
Jul 17, 2018·Neural Plasticity·Olga BorodovitsynaDaniel Chandler
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Jul 6, 2021·Journal of Alzheimer's Disease : JAD·Rebecca BeardmoreDelphine Boche
Oct 31, 2021·The European Journal of Neuroscience·Chin-An Wang, Douglas P Munoz

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