Projections from the dorsomedial division of the bed nucleus of the stria terminalis to hypothalamic nuclei in the mouse.

The Journal of Comparative Neurology
Marie BarbierSophie Croizier

Abstract

As stressful environment is a potent modulator of feeding, we seek in the present work to decipher the neuroanatomical basis for an interplay between stress and feeding behaviors. For this, we combined anterograde and retrograde tracing with immunohistochemical approaches to investigate the patterns of projections between the dorsomedial division of the bed nucleus of the stria terminalis (BNST), well connected to the amygdala, and hypothalamic structures such as the paraventricular (PVH) and dorsomedial (DMH), the arcuate (ARH) nuclei and the lateral hypothalamic areas (LHA) known to control feeding and motivated behaviors. We particularly focused our study on afferences to proopiomelanocortin (POMC), agouti-related peptide (AgRP), melanin-concentrating-hormone (MCH) and orexin (ORX) neurons characteristics of the ARH and the LHA, respectively. We found light to intense innervation of all these hypothalamic nuclei. We particularly showed an innervation of POMC, AgRP, MCH and ORX neurons by the dorsomedial and dorsolateral divisions of the BNST. Therefore, these results lay the foundation for a better understanding of the neuroanatomical basis of the stress-related feeding behaviors.

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Citations

Feb 27, 2021·Frontiers in Behavioral Neuroscience·William J Giardino, Matthew B Pomrenze
Jun 2, 2021·Translational Neurodegeneration·David BayerFrancesco Roselli

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Datasets Mentioned

BETA
ABIN1983384

Key Resources (RRID) Mentioned

MGI
IMSR_JAX
AB_2315142
AB_10000080
AB_390204
AB_2616562
AB_518673
AB_2298772
AB_2571743

Software Mentioned

Imaris
AnalySIS

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