PMID: 7543365Feb 1, 1995Paper

Projections of neurochemically specified neurons in the porcine colon

Histochemistry and Cell Biology
M BarbiersD W Scheuermann

Abstract

The intramural projections of nerve cells containing serotonin (5-HT), calcitonin gene-related peptide (CGRP), vasoactive intestinal peptide (VIP) and nitric oxide synthase or reduced nicotinamide adenine dinucleotide phosphate diaphorase (NOS/NADPHd) were studied in the ascending colon of 5- to 6-week-old pigs by means of immunocytochemistry and histochemistry in combination with myectomy experiments. In control tissue of untreated animals, positive nerve cells and fibres were common in the myenteric and outer submucous plexus and, except for 5-HT-positive perikarya, immunoreactive cell bodies and fibres were also observed in the inner submucous plexus. VIP- and NOS/NADPHd-positive nerve fibres occurred in the ciruclar muscle layer while VIP was also abundant in nerve fibres of the mucosal layer. 5-HT- and CGRP-positive nerve fibres were virtually absent from the aganglionic nerve networks. In the submucosal layer, numerous paravascular CGRP-immunoreactive (IR) nerve fibres were encountered. Myectomy studies revealed that 5-HT-, CGRP-, VIP- and NOS/NADPHd-positive myenteric neurons all displayed anal projections within the myenteric plexus. In addition, some of the serotonergic myenteric neurons projected anally to the outer s...Continue Reading

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Citations

Oct 16, 2008·Cell and Tissue Research·Zheng-Dong QuJohn B Furness
Aug 26, 1998·Acta histochemica·I I Stoyanova, M V Gulubova
Aug 23, 2001·Autonomic Neuroscience : Basic & Clinical·M StorrH D Allescher
Feb 3, 1999·Annals of the New York Academy of Sciences·M FujimiyaA Kuwahara
Mar 21, 1998·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·H SannM Schemann
Dec 10, 2008·The Journal of Physiology·Kathleen B NealJoel C Bornstein
Jan 31, 2007·Neuroscience·K B Neal, J C Bornstein
Jan 28, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T OkamotoT K Smith
Feb 19, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·C PorcherM Henry
Aug 20, 2005·Pharmacological Reviews·Noboru Toda, Arnold G Herman
Jan 27, 2021·Animals : an Open Access Journal From MDPI·Andrea ToschiEster Grilli

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