Prokinetic effects of a ghrelin receptor agonist GHRP-6 in diabetic mice.

World Journal of Gastroenterology : WJG
Qi ZhengKai-Xing Ai

Abstract

To investigate the effects of a ghrelin receptor agonist GHRP-6 on delayed gastrointestinal transit in alloxan-induced diabetic mice. A diabetic mouse model was established by intraperitoneal injection with alloxan. Mice were randomized into two main groups: normal mice and diabetic mice treated with GHRP-6 at doses of 0, 20, 50, 100 and 200 microg/kg ip. Gastric emptying (GE), intestinal transit (IT), and colonic transit (CT) were studied in mice after they had a phenol red meal following injection of GHRP-6. Based on the most effective GHRP-6 dosage, atropine was given at 1 mg/kg for 15 min before the GHRP-6 injection for each measurement. The mice in each group were sacrificed 20 min later and the percentages of GE, IT, and CT were calculated. Percentages of GE, IT, and CT were significantly decreased in diabetic mice as compared to control mice. In the diabetic mice, GHRP-6 improved both GE and IT, but not CT. The most effective dose of GHRP-6 was 200 microg/kg and atropine blocked the prokinetic effects of GHRP-6 on GE and IT. GHRP-6 accelerates delayed GE and IT, but has no effect on CT in diabetic mice. GHRP-6 may exert its prokinetic effects via the cholinergic pathway in the enteric nervous system, and therefore, has t...Continue Reading

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Apr 30, 2008·World Journal of Gastroenterology : WJG·Wen-Cai QiuKai-Xing Ai

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Citations

Aug 20, 2010·International Journal of Peptides·Hanaa S Sallam, Jiande D Z Chen
Jun 6, 2009·Drugs·Jing MaMichael Horowitz
Aug 6, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·B AvauI Depoortere
May 12, 2009·Pharmacology & Therapeutics·Betty De SmetInge Depoortere
Apr 2, 2011·Peptides·Beverley Greenwood-Van MeerveldRichard Nelson
Nov 1, 2018·The Journal of Pharmacology and Experimental Therapeutics·Ehsan N MohammadiBeverley Greenwood-Van Meerveld

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