Prokineticin receptor-1 induces neovascularization and epicardial-derived progenitor cell differentiation

Arteriosclerosis, Thrombosis, and Vascular Biology
Kyoji UrayamaCanan G Nebigil

Abstract

Identification of novel factors that contribute to myocardial repair and collateral vessel growth hold promise for treatment of heart diseases. We have shown that transient prokineticin receptor-1 (PKR1) gene transfer protects the heart against myocardial infarction in a mouse model. Here, we investigated the role of excessive PKR1 signaling in heart. Transgenic mice overexpressing PKR1 in cardiomyocytes displayed no spontaneous abnormalities in cardiomyocytes but showed an increased number of epicardial-derived progenitor cells (EPDCs), capillary density, and coronary arterioles. Coculturing EPDCs with H9c2 cardiomyoblasts overexpressing PKR1 promotes EPDC differentiation into endothelial and smooth muscle cells, mimicking our transgenic model. Overexpressing PKR1 in H9c2 cardiomyoblasts or in transgenic hearts upregulated prokineticin-2 levels. Exogenous prokineticin-2 induces significant outgrowth from neonatal and adult epicardial explants, promoting EPDC differentiation. These prokineticin-2 effects were abolished in cardiac explants from mice with PKR1-null mutation. Reduced capillary density and prokineticin-2 levels in PKR1-null mutant hearts supports the hypothesis of an autocrine/paracrine loop between PKR1 and prokin...Continue Reading

References

Jun 11, 2002·Biochemical and Biophysical Research Communications·Yasushi MasudaMasahiko Fujino
Nov 13, 2002·Biochimica Et Biophysica Acta·Takatoshi SogaKiyoshi Furuichi
Feb 27, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jennifer LeCouterNapoleone Ferrara
May 10, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Canan G NebigilLuc Maroteaux
Dec 31, 2003·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·A Wessels, J M Pérez-Pomares
Nov 19, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jennifer LeCouterNapoleone Ferrara
Apr 30, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Satoshi MurasawaTakayuki Asahara
May 24, 2005·Journal of Leukocyte Biology·Marion DorschChristopher C Fraser
Nov 22, 2005·British Journal of Pharmacology·Cataldo MartucciPaola Sacerdote
Feb 4, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Juan A GuadixJosé M Pérez-Pomares
Feb 10, 2006·Journal of Molecular and Cellular Cardiology·Amy L HowesJoan Heller Brown
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Shun-Ichiro MatsumotoYasufumi Shigeyoshi
Jun 7, 2006·Developmental Biology·Boudewijn P T KruithofMaurice J B van den Hoff
Nov 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jia-Da LiQun-Yong Zhou
Nov 17, 2006·Molecular Pain·Wang-Ping HuQun-Yong Zhou
Jan 5, 2007·Proceedings of the National Academy of Sciences of the United States of America·Haydn M ProsserElizabeth S Maywood
Feb 28, 2007·Biochimica Et Biophysica Acta·Elly S W NganPaul K H Tam
Apr 20, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kyoji UrayamaCanan G Nebigil
Dec 7, 2007·The European Journal of Neuroscience·Haydn M ProsserMaeve A Caldwell

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Citations

Mar 21, 2012·Proceedings of the National Academy of Sciences of the United States of America·Michelle Y ChengRobert M Sapolsky
May 7, 2009·Antioxidants & Redox Signaling·Ebo D de Muinck
Aug 23, 2011·Cardiovascular Research·Mounia BoulberdaaCanan G Nebigil
Nov 9, 2011·PloS One·Yohann BernardLaurent Désaubry
Dec 22, 2011·Future Cardiology·Nicola Smart, Paul R Riley
Jan 16, 2009·Therapeutic Advances in Cardiovascular Disease·Kenichi Yamahara, Hiroshi Itoh
Mar 20, 2010·Circulation Research·Harold E Olivey, Eric C Svensson
Sep 28, 2016·Hypertension·Canan G Nebigil
Jan 29, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Mounia BoulberdaaCanan G Nebigil
Apr 19, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Paul R Riley
Sep 15, 2009·Birth Defects Research. Part C, Embryo Today : Reviews·Ioan Ovidiu Sirbu, Petra Pandur
Nov 26, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P R WadeP J Hornby
May 19, 2010·Journal of Cellular and Molecular Medicine·R CarmonaR Muñoz-Chápuli
Jul 1, 2009·International Journal of Experimental Pathology·Nicola SmartPaul R Riley
Oct 20, 2015·Scientific Reports·Cinzia SeveriniLucia Negri
Dec 22, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Célia GuiliniCanan G Nebigil
Apr 17, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Himanshu AroraCanan G Nebigil
Apr 28, 2017·Frontiers in Cardiovascular Medicine·Canan G Nebigil
May 17, 2017·Frontiers in Cell and Developmental Biology·Angel DueñasDiego Franco
Jul 22, 2015·Current Opinion in Endocrinology, Diabetes, and Obesity·Jean-Jacques Von Hunolstein, Canan G Nebigil
Apr 8, 2017·International Journal of Endocrinology·Ana Silvia CorlanMarius Raica
Feb 11, 2020·Frontiers in Cardiovascular Medicine·Anais AudebrandCanan G Nebigil
Nov 17, 2009·Biochemical Society Transactions·Paul R Riley, Nicola Smart
Nov 20, 2016·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Nicola Smart
Jun 29, 2018·Nature Reviews. Cardiology·Jingli Cao, Kenneth D Poss
Jun 18, 2013·Journal of Developmental Biology·Thu Lan NguyenCanan G Nebigil
Mar 19, 2021·Frontiers in Pharmacology·Roberta LattanziAldo Badiani
Dec 9, 2009·Journal of Molecular and Cellular Cardiology·Federica LimanaMaurizio C Capogrossi
May 4, 2016·Neuropharmacology·Elisa LanducciDomenico E Pellegrini-Giampietro
Sep 3, 2018·Trends in Cardiovascular Medicine·Canan G Nebigil, Laurent Désaubry
Sep 17, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Laurent DésaubryCanan G Nebigil
Jun 5, 2012·Heart, Lung & Circulation·James J H Chong
Jul 28, 2021·Nanomedicine : Nanotechnology, Biology, and Medicine·Chunjuan ZhangJoonghoon Park
Oct 13, 2010·Pharmacology & Therapeutics·Federica LimanaAntonia Germani

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