Prolactin administration stimulates rat hepatic DNA synthesis

Biochemical and Biophysical Research Communications
A R BuckleyD H Russell

Abstract

Prolactin is an important growth modulatory hormone in fetal and adult tissues. Its administration stimulates enzymatic markers of the G1 phase of cell cycle in rat liver and other tissues. To determine the effects of prolactin administration on hepatic DNA synthesis (S phase), rats received prolactin at 12 hour intervals for 48 hours and DNA synthesis was assessed by [3H]-thymidine incorporation. Prolactin administration stimulated DNA synthesis 2-4 fold above controls in the livers of adult and weanling animals. Increased incorporation of radiolabel was associated with the nucleus of hepatoparenchymal cells. These data support the hypothesis that prolactin may be a physiological regulator of hepatic DNA synthesis. Further, since stress stimulates prolactin secretion, we suggest that prolactin may participate in the hepatic compensatory hyperplasia elicited by the stress associated with partial hepatectomy.

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Citations

Oct 20, 1998·Biulleten' eksperimental'noĭ biologii i meditsiny·A N OrlovaA N Smirnov
Jan 1, 1989·Life Sciences·M D SauroD F Fitzpatrick
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Jul 1, 1992·Immunology Letters·K Skwarło-Sońta
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Aug 1, 1991·Molecular and Cellular Endocrinology·P D CroweH Rui
Mar 13, 1990·European Journal of Pharmacology·D H RussellH E Laird
Mar 4, 1998·Molecular and Cellular Endocrinology·R PiccolettiP Maroni
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A R BuckleyD H Russell
Jan 1, 1990·Journal of Toxicology and Environmental Health·D CampenG Lucier
Apr 30, 1991·Biochemical and Biophysical Research Communications·W J DeVitoC Avakian
Feb 1, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Joonyong LeeGuoli Dai
Sep 1, 1993·The Journal of Investigative Dermatology·G GirolomoniP R Bergstresser
Jul 1, 1992·Archives of Biochemistry and Biophysics·A R BuckleyC W Putnam

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