PMID: 9641506Jun 26, 1998Paper

Prolactin and interleukin-6 in neuropsychiatric lupus erythematosus

Clinical Rheumatology
L J JaraL R Espinoza

Abstract

We investigated the levels of prolactin (PRL) and interleukin-6 (IL-6) in the cerebrospinal fluid (CSF) and serum of systemic lupus erythematosus patients with central nervous system involvement (CNS-SLE), and examined whether PRL and IL-6 have a relationship. Serum and CSF PRL and IL-6 were measured in the following groups of patients and controls: group I: seven patients with CNS-SLE; group II: three SLE patients without CNS involvement (non CNS-SLE); group III: 10 patients with neurocysticercosis; and group IV: six healthy women. The patients were clinically assessed. CSF PRL and IL-6 were elevated in group I (CNS-SLE) in comparison with all other groups (p<0.001). In addition, four of seven patients had higher levels of IL-6 and PRL in CSF than in serum. A positive correlation between PRL and IL-6 in CSF of SLE was observed (r=0.88, p<0.001). The mean serum PRL concentrations were not significantly different in all groups, but high levels of IL-6 were found in the serum of group I in comparison with groups II and IV (p<0.001). The serum levels of group III were not different from those of group I. These results demonstrate the presence of intrathecal synthesis and elevations of CSF PRL and IL-6 in active CNS-SLE involvement...Continue Reading

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Citations

Sep 28, 2004·Rheumatology International·Antoni HrycekWitold Szkróbka
Jul 21, 2009·Modern Rheumatology·Petros Efthimiou, Michelle Blanco
Feb 3, 2011·Clinical Reviews in Allergy & Immunology·Hedi OrbachYehuda Shoenfeld
Aug 6, 2002·Journal of Neuroimmunology·Boris SakicHenry Szechtman
Mar 25, 2000·Annals of the Rheumatic Diseases·G S DeanD A Isenberg
Jul 10, 2010·Journal of Biomedicine & Biotechnology·Hiroshi OkamotoHisashi Yamanaka
Feb 12, 2014·Nature Reviews. Rheumatology·John G Hanly
Jun 1, 2005·Rheumatic Diseases Clinics of North America·John G Hanly
Dec 14, 2011·Autoimmunity Reviews·Shahar ShellyHedi Orbach
Oct 16, 2007·Rheumatic Diseases Clinics of North America·Susanne M Benseler, Earl D Silverman
Nov 1, 2008·Arthritis and Rheumatism·Elizabeth KozoraChristopher M Filley
May 6, 2014·Frontiers in Neuroendocrinology·S T NgoP A McCombe
Mar 23, 2005·Biological Psychiatry·Boris SakicJason M Millward
Jun 15, 2004·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Elena PeevaBetty Diamond
Sep 10, 2005·Best Practice & Research. Clinical Rheumatology·John G Hanly, Melanie J Harrison
Apr 12, 2005·Pediatric Clinics of North America·Susanne M Benseler, Earl D Silverman
Dec 3, 2014·General and Comparative Endocrinology·Steve HarveyCarlos Arámburo
Apr 22, 2015·Cytokine·Heeju Ryu, Yeonseok Chung
Nov 28, 2001·Lupus·L J JaraJ Alvarez-Nemegyei
Jan 29, 2017·Immunologic Research·Luis J JaraLuis R Espinoza
May 16, 2001·Current Rheumatology Reports·J G Hanly
Jun 8, 2019·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Yamei TangXiudeng Yang

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