PMID: 589073Nov 5, 1977

Prolactin concentrations in ovulatory but infertile women: treatment with bromocriptine

British Medical Journal
E A LentonI D Cooke

Abstract

We measured basal plasma prolactin concentrations (in samples obtained during the early follicular phase) in 25 normal (control) women and in a similar group of 40 patients with a long-standing history of infertility. The infertile patients were all ovulating regularly, and had been unsuccessfully treated with clomiphene and in some cases dydrogesterone and human menopausal gonadotrophin. Although none of the patients had plasma prolactin concentrations greater than 1000 muU/ml, 47.5% of the estimations were greater than 1 standard deviation (SD) above the mean established for our control group. This difference was highly significant (P less than 0.001). Treatment with various bromocriptine regimens effectively reduced prolactin concentrations to below normal in all cases, and 16 pregnancies followed-13 during bromocriptine treatment and three in the first post-treatment cycle. The cumulative conception rate was 63.4% after 10 months' treatment.

References

Jan 1, 1977·British Journal of Obstetrics and Gynaecology·R J PepperellH G Burger
Dec 20, 1975·British Medical Journal·M O ThornerA E Jones
May 25, 1974·British Medical Journal·M O ThornerG M Besser
Jan 1, 1974·The Journal of Clinical Endocrinology and Metabolism·B M Sherman, S G Korenman

Citations

Feb 1, 1979·Irish Journal of Medical Science·R R O'Moore
Feb 1, 1979·Irish Journal of Medical Science·G W Pennington, S Naik
Apr 1, 1981·European Journal of Obstetrics, Gynecology, and Reproductive Biology·B FredricssonI Messinis
Aug 1, 1989·European Journal of Obstetrics, Gynecology, and Reproductive Biology·C A IfflandJ L Beynon
Aug 1, 1979·British Journal of Obstetrics and Gynaecology·O YlikorkalaA Kauppila
Jun 1, 1985·British Journal of Obstetrics and Gynaecology·R J Pepperell, J C McBain
Jun 1, 1987·British Journal of Obstetrics and Gynaecology·C M GlazenerM G Hull
Feb 1, 1981·American Journal of Obstetrics and Gynecology·J V KredentserJ Z Scott
Dec 23, 2017·The Journal of Clinical Endocrinology and Metabolism·Tahereh Orouji JokarPouneh K Fazeli
Jul 20, 2007·The Cochrane Database of Systematic Reviews·E HughesP Vandekerckhove
Apr 1, 1979·Clinical Endocrinology·E A LentonI D Cooke
Mar 1, 1982·Clinical Endocrinology·Y K SoongS L Jeffcoate
Jan 1, 1979·Journal of Endocrinological Investigation·T RantaM Seppälä
Jun 1, 1990·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·C M GlazenerM G Hull

Related Concepts

Parlodel
Subfecundity
Subfertility, Female
Ovulation
Prolactin

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