Prolactin deficiency is independently associated with reduced insulin-like growth factor I status in severely growth hormone-deficient adults

The Journal of Clinical Endocrinology and Metabolism
A MukherjeeS M Shalet

Abstract

In adult life, considerable overlap in IGF-I status exists between normal and severely GH-deficient (GHD) subjects defined by conventional dynamic testing of GH secretion. IGF-I is not therefore widely viewed as a reliable diagnostic marker for GHD. Recognized factors influencing serum IGF-I level in GHD include age, gender, timing of onset of GHD, and exogenous estrogen therapy, but these do not fully explain GH/IGF-I discordance in severe GHD. The primary structures of prolactin and GH are closely related. Effects of hypoprolactinemia are not well described in humans, but laboratory studies suggest a role for prolactin in hepatic IGF-I release, possibly through a signal transducer and activator of transcription 5 (STAT5) pathway. The purpose of this study was to evaluate a potential contribution of prolactin to IGF-I status in severely GHD adults. Using multiple regression analysis techniques, contributions of the following variables to age-adjusted IGF-I sd scores were evaluated in 162 (85 female) GHD adults: gender, timing of onset of GHD, presence or absence of prolactin deficiency, body mass index, number of additional pituitary deficits, and underlying pathology. Childhood onset GHD (P < 0.0001) and presence of prolactin...Continue Reading

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Citations

Mar 14, 2008·Pituitary·Olivia Pereira, John S Bevan
Feb 27, 2013·Nature Reviews. Endocrinology·Johannes D Veldhuis
Mar 29, 2007·Hormone Research·K Kaushal, S M Shalet
Aug 18, 2009·European Journal of Endocrinology·A Mukherjee, S M Shalet
Aug 18, 2009·European Journal of Endocrinology·Helena Filipsson, Gudmundur Johannsson
Jun 9, 2007·Journal of Endocrinological Investigation·Y ToledanoI Shimon
Feb 25, 2009·Clinical and Experimental Immunology·A MukherjeeS M Shalet
Dec 31, 2009·Clinical Endocrinology·Annice MukherjeeStephen Shalet
Apr 26, 2014·PloS One·Olivier GalyOlivier Hue
Aug 1, 2016·Current Treatment Options in Oncology·Cecilia Follin, Eva Marie Erfurth
Apr 5, 2016·Lancet·Claire E HighamStephen M Shalet
Sep 28, 2007·Pituitary·John Ching, Phillip D K Lee

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