PMID: 6102886May 26, 1980

Prolactin in cerebrospinal fluid: a probable site of prolactin autoregulation

Brain Research
G NicholsonJ S Kizer


The purpose of this study was to examine the thesis that increasing concentrations of prolactin within the cerebrospinal fluid (CSF) increase the activity of dopaminergic terminals within the median eminence and that this increased dopaminergic activity is temporally associated with a suppression of endogenous prolactin secretion. To avoid difficulties encountered in performing catecholamine turnovers in the undisturbed rat, the measurement of tyrosine hydroxylase was validated as an index of dopaminergic activity within the median eminence. In the median eminence, but not the medial preoptic area, parallel increases in the activity of tyrosine hydroxylase and the turnover of dopamine (but not norepinephrine) occurred following hyperprolactinemia. Twenty-six hours but not 2.5 h after the subcutaneous administration of ovine prolactin, the activity of tyrosine hydroxylase was increased in the median eminence, and endogenous prolactin secretion was inhibited. During a 26 h continuous intracerebroventricular (icv) infusion (88 ng/h) of rat prolactin, there was a complete suppression of endogenous prolactin secretion. Twenty-six but not 2.5 h after the initiation of the icv infusion of prolactin, there was an increase in tyrosine h...Continue Reading


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Related Concepts

Pituitary Hormones, Anterior
Catecholamine [EPC]
Preoptic Areas
Transcription Initiation
Cerebrospinal Fluid
Norepinephrine, (+, -)-Isomer
Process of Secretion
Visual Suppression
PRL gene

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