PMID: 15223776Jun 30, 2004Paper

Prolactin in eyes of patients with retinopathy of prematurity: implications for vascular regression

Investigative Ophthalmology & Visual Science
Z DueñasC Clapp

Abstract

Disruption of the anti-angiogenic environment of the retina leads to neovascular eye diseases, including retinopathy of prematurity (ROP). Prolactin (PRL), the hormone originally associated with milk secretion, is proteolytically processed to 16K-PRL, a fragment with potent antiangiogenic, proapoptotic effects. Whether 16K-PRL is produced in eyes of patients with ROP and promotes the regression of intraocular blood vessels associated with this disease was investigated. PRL was quantified in the aqueous humor, subretinal fluid, and serum from patients with stage 5 ROP and in patients with non-neovascular eye disorders. Intraocular expression of PRL was evaluated by RT-PCR, in situ hybridization, and Western blot analysis. AntiPRL antibodies were injected intravitreously in neonatal rats, and apoptosis of hyaloid vessels determined by TUNEL and ELISA. PRL was elevated in ocular fluids and serum from ROP patients. There was no correlation between PRL in ocular fluids and its level in serum, whereas PRL in aqueous humor and subretinal fluid were significantly correlated. PRL mRNA was expressed in blood vessels and leukocytes within retrolental fibrovascular membranes of ROP patients, and these membranes contained a 16 kDa immunorea...Continue Reading

Citations

Jan 22, 2008·Journal of Mammary Gland Biology and Neoplasia·Carmen ClappGonzalo Martínez de la Escalera
Jun 26, 2012·Current Heart Failure Reports·Denise Hilfiker-KleinerKaren Sliwa
Nov 30, 2010·Hormones & Cancer·J M Faupel-BadgerB K Vonderhaar
Feb 12, 2009·Retina·Hugo Quiroz-MercadoRobinson Vernon Paul Chan
Oct 16, 2009·Early Human Development·C Romagnoli
Dec 22, 2007·Experimental Eye Research·José C RiveraCarmen Clapp
Sep 4, 2007·Trends in Endocrinology and Metabolism : TEM·Carmen ClappGonzalo Martínez de la Escalera
Sep 14, 2011·IUBMB Life·Jakob TriebelCarmen Clapp
Dec 3, 2014·General and Comparative Endocrinology·Steve HarveyCarlos Arámburo
Jan 13, 2018·Frontiers in Endocrinology·Jakob TriebelThomas Bertsch
Aug 7, 2007·Laboratory Investigation; a Journal of Technical Methods and Pathology·Carmen GonzálezCarmen Clapp
Sep 6, 2007·American Journal of Physiology. Endocrinology and Metabolism·Sabine ErdmannKatharina Spanel-Borowski
Jun 12, 2008·American Journal of Physiology. Endocrinology and Metabolism·Carmen ClappGonzalo Martínez de la Escalera
Oct 1, 2009·Physiological Reviews·Carmen ClappGonzalo Martínez De La Escalera
Feb 13, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Rodrigo M AroñaGonzalo Martínez de la Escalera
Aug 28, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jakob TriebelCarmen Clapp
Apr 27, 2019·Frontiers in Endocrinology·Jakob TriebelCarmen Clapp
Apr 13, 2006·Journal of Cell Science·Yazmín MacotelaCarmen Clapp

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