Prolactin-induced production of cytokines in macrophages in vitro involves JAK/STAT and JNK MAPK pathways

International Immunology
Anurag Tripathi, Ajit Sodhi

Abstract

Macrophages play a crucial role in host immunosurveillance against pathogens and malignancies. The enhanced productions of pro-inflammatory cytokines are central to the regulatory role of macrophages and induction of robust immune response. The excessive inflammatory response of macrophages can result into pathological conditions in host. We have previously reported that prolactin (PRL) induces the production of nitric oxide (NO) and tumor necrosis factor (TNF)-alpha in murine peritoneal macrophages. It was suggested that protein tyrosine kinases (PTKs), mitogen-activated protein kinases (MAPKs) and Ca(++) signaling were involved in the NO production by macrophages on PRL treatment. In this manuscript, we investigated the role of PTKs [Janus kinase (JAK) 2 and phosphoinositide 3-kinase (PI3K)] and c-Jun N-terminal kinase (JNK) MAPK in PRL-induced activation of murine peritoneal macrophages. It is reported that PRL-induced activation of macrophages in vitro is dependent on JAK/signal transducers and activators of transcription (STAT) and JNK MAPK-signaling pathways. It is observed that pre-treatment of macrophages with JNK inhibitor, SP600125; tyrosine kinase inhibitor, genistein; PI3K inhibitor, Wortmannin and JAK2 inhibitor, A...Continue Reading

References

Sep 1, 1992·Molecular and Cellular Endocrinology·K D O'NealL Y Yu-Lee
Oct 17, 1991·Nature·B J PulvererJ R Woodgett
Feb 1, 1987·The Journal of Clinical Investigation·C F Nathan
Jan 1, 1984·Annual Review of Immunology·D O Adams, T A Hamilton
Jan 1, 1982·Immunological Reviews·S B Mizel
Jul 19, 1994·Proceedings of the National Academy of Sciences of the United States of America·M DavidA C Larner
Dec 1, 1994·Molecular and Cellular Biology·H K SlussR J Davis
Aug 5, 1994·Science·Z Galcheva-GargovaR J Davis
Apr 1, 1994·Molecular and Cellular Biology·C E DabrowskiP A Schaffer
Jan 1, 1993·Annual Review of Immunology·R N Germain, D H Margulies
Jun 28, 1996·The Journal of Biological Chemistry·Y Y LoT F Cruz
Oct 18, 1996·The Journal of Biological Chemistry·P Gómez del ArcoJ M Redondo
May 1, 1997·Proceedings of the Society for Experimental Biology and Medicine·L Y Yu-Lee
Nov 14, 1997·Journal of Neuroimmunology·L MateraC Cavaliere
Jun 25, 1998·Current Opinion in Immunology·K D LiuM A Goldsmith
Jul 11, 1998·The Journal of Endocrinology·C V ClevengerJ B Kline
Sep 1, 1999·Proceedings of the National Academy of Sciences of the United States of America·R L Haspel, J E Darnell
May 19, 2000·Cytokine & Growth Factor Reviews·K Takeda, S Akira
Oct 24, 2000·Molecular Endocrinology·K L SchwertfegerS M Anderson
Oct 18, 2001·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·P IgazA Falus
Nov 6, 2001·Journal of Neuroimmunology·Z DogusanE L Hooghe-Peters
Jun 20, 2002·Veterinary Immunology and Immunopathology·Michael P Murtaugh, Dennis L Foss
Aug 23, 2002·Immunological Reviews·Emil R Unanue
Mar 17, 2004·Journal of Cell Science·Jason S RawlingsDouglas A Harrison
Sep 17, 2004·Genes & Development·Matthew S Hayden, Sankar Ghosh
Jan 18, 2006·Pituitary·Annamaria De BellisAntonio Bellastella
Dec 13, 2006·Clinical & Developmental Immunology·Luis J JaraFrancisco Blanco

❮ Previous
Next ❯

Citations

Feb 20, 2013·Fish Physiology and Biochemistry·Marco ParedesEnrique Montiel-Eulefi
Feb 7, 2012·The Journal of Biological Chemistry·Chao-Hung ChenShyi-Jang Shin
Jun 5, 2013·Journal of Inflammation·Gonzalo López-RincónCiro Estrada-Chávez
Aug 2, 2011·Molecular and Cellular Endocrinology·María Eugenia MatzkinMónica Beatriz Frungieri
May 6, 2009·Journal of Cellular Biochemistry·Michelino Di RosaLucia Malaguarnera
Apr 8, 2009·European Journal of Immunology·Naoko KandaShinichi Watanabe
Oct 1, 2015·Immunity & Ageing : I & a·Georg PongratzL Cornelius Bollheimer
Jun 13, 2009·Biochemical and Biophysical Research Communications·Maki NumazakiNaoya Kojima
Dec 3, 2014·Autoimmunity Reviews·Massimo CostanzaRosetta Pedotti
Feb 28, 2018·Frontiers in Immunology·Vânia Vieira BorbaYehuda Shoenfeld
Sep 10, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Víctor H OlavarríaVictoriano Mulero
Apr 9, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·X TanJ M Hughes
Jun 24, 2017·Journal of Leukocyte Biology·Man Wai TangKris A Reedquist
Feb 27, 2021·Journal of Ovarian Research·Sima ChaudhariKapaettu Satyamoorthy
Mar 5, 2021·Reviews in the Neurosciences·Edgar Ramos-MartinezMarco Cerbon
Jun 20, 2020·Frontiers in Neuroendocrinology·Pedro MarquesMárta Korbonits
May 1, 2021·International Journal of Molecular Sciences·Yulong SunYuanyuan Kuang
Aug 7, 2021·PloS One·Amira AlkharusiFahad Zadjali
Apr 22, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Luan Luan, Zhiyuan Liang

❮ Previous
Next ❯

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.