Prolactin induces chitotriosidase gene expression in human monocyte-derived macrophages

Immunology Letters
Lucia MalaguarneraS Musumeci

Abstract

Human chitotriosidase (Chit), a chitinolytic enzyme, is a member of the chitinase family. In human's plasma Chit activity have been proposed as a biochemical marker of macrophage activation in several lysosomal diseases. Recently we found that Chit activity is higher in patients affected by Plasmodium falciparum malaria infection suggesting that chitotriosidase may induce an immunological response. The pituitary hormone prolactin (PRL) is a multifunctional polypeptide also produced by immune cells and represents a key component of the neuroendocrine-immune loop. The presence of PRL receptors in macrophage suggests that PRL is involved in regulating functions in these cells. Our objective in this study was to investigate the effect of PRL in human monocyte-derived macrophages (HMMs) on Chit production. Administration of PRL in HMMs was found to increase both expression and activity of Chit in a time and dose dependent manner as quantified, respectively, by real time PCR and Chit activity assay. PRL-treated monocyte-derived macrophages showed also an enhanced release of superoxide anion (O2-) release. Our observations confirm that PRL regulates HMMs activation and suggest, for the first time, that it influences immune function al...Continue Reading

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Citations

Nov 16, 2006·Journal of Human Genetics·Ignazio PirasGiuseppe Vona
Nov 3, 2009·Journal of Human Genetics·Lucia MalaguarneraMariano Malaguarnera
May 19, 2005·Clinical Chemistry and Laboratory Medicine : CCLM·Michelino Di RosaLucia Malaguarnera
Sep 14, 2006·Journal of Vector Borne Diseases·Maria MusumeciSalvatore Musumeci
Feb 18, 2016·Enzyme Research·Mohamed A ElmonemElena N Levtchenko
Feb 9, 2010·The Journal of Sexual Medicine·Mohammad Reza Safarinejad, Shiva Safarinejad
Dec 27, 2008·The Journal of Investigative Dermatology·Kerstin FoitzikRalf Paus
Aug 19, 2007·Blood Cells, Molecules & Diseases·Pauline LeeErnest Beutler
Nov 5, 2014·Pediatrics International : Official Journal of the Japan Pediatric Society·Sezgin GunesNilgun Kultursay
May 6, 2009·Journal of Cellular Biochemistry·Michelino Di RosaLucia Malaguarnera
Jul 5, 2006·The European Journal of Neuroscience·Michelino Di RosaLucia Malaguarnera
Sep 14, 2012·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Michelino Di RosaLucia Malaguarnera
Jul 19, 2006·International Immunopharmacology·Linsong YangYayi Hou
Dec 22, 2011·International Journal of Microbiology·Karina Vega, Markus Kalkum
Jul 17, 2007·Respiratory Medicine·Elena BargagliPaola Rottoli
Dec 3, 2014·Autoimmunity Reviews·Massimo CostanzaRosetta Pedotti
Dec 6, 2016·International Journal of Molecular Sciences·Massimo Costanza, Rosetta Pedotti
Jul 20, 2006·The American Journal of Gastroenterology·Lucia MalaguarneraMariano Malaguarnera
May 20, 2008·Respiration; International Review of Thoracic Diseases·Elena BargagliPaola Rottoli
Oct 11, 2005·International Immunology·Marco van EijkJohannes M F G Aerts
Mar 5, 2021·Reviews in the Neurosciences·Edgar Ramos-MartinezMarco Cerbon

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