Prolactin induces switching of T-cell receptor gene expression from alpha to gamma in rat Nb2 pre-T lymphoma cells(1)

Biochemical and Biophysical Research Communications
Y HosokawaK Nakashima

Abstract

Prolactin (PRL) is considered to be an immunomodulator. This study was conducted to analyze the actions of PRL on the gene expressions for T-cell receptor (TCR) chains in a fat pre-T lymphoma cell line, Nb2. PRL remarkably stimulated the gene expression for TCR gamma chain within 4 h and suppressed TCR alpha chain mRNA expression within 8 h in Nb2 cells. The expression of TCR beta mRNA in the cells was concomitantly, but to a less extent, repressed by the hormone treatment. These results suggest that PRL may participate in the regulation of mammalian T-cell differentiation and development.

Citations

Jun 6, 2003·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Flora IppolitiTullio Frediani
Jul 19, 2006·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Flora IppolitiTullio Frediani
Jan 18, 2006·Pituitary·Annamaria De BellisAntonio Bellastella
Aug 19, 2000·Endocrine Reviews·W Savino, M Dardenne
Apr 8, 2009·European Journal of Immunology·Naoko KandaShinichi Watanabe
Oct 16, 2002·Developmental and Comparative Immunology·Lili YangAmeae M Walker

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