Prolactin prevents mitochondrial dysfunction induced by glutamate excitotoxicity in hippocampal neurons

Neuroscience Letters
Nadia A Rivero-SeguraM Cerbón

Abstract

Prolactin (PRL) is a pleiotropic hormone secreted by several cells and tissues in the body, such as mammary glands, T-lymphocytes, hypothalamus, among others. This hormone possess neuroprotective properties against glutamate-excitotoxicity through the activation of NF-kB, suggesting it could exert an antioxidant action. However, the role of PRL on the antioxidant defense during glutamate-induced excitotoxicity is not clear to date. Therefore, in the present study, we have evaluated the effect of PRL on SOD activity and protein content of both of its isoforms (Mn2+-SOD and Cu2+/Zn2+-SOD), as well as, its action on mitochondrial activity in primary culture of hippocampal neurons of rats. Additionally, we have evaluated the possible antioxidant effect of PRL through the determination of lipid peroxidation products (LPO), measured as malondialdehyde (MDA). Results show that PRL enhances the activity and the protein content of Mn2+-SOD and Cu2+/Zn2+-SOD in neurons exposed to glutamate-induced excitotoxicity. Moreover, our results demonstrate that PRL prevents mitochondrial dysfunction induced by glutamate and significantly decreases the levels of LPO products. To our knowledge, this is the first time that a potential antioxidant eff...Continue Reading

Citations

Jul 24, 2020·Cellular and Molecular Neurobiology·Rodrigo G Mira, Waldo Cerpa
Aug 16, 2019·Frontiers in Neuroendocrinology·L S KalinichenkoC P Müller
Nov 26, 2019·Experimental Gerontology·Xianyi LinXin Yu
Mar 5, 2021·Reviews in the Neurosciences·Edgar Ramos-MartinezMarco Cerbon
Mar 27, 2021·Frontiers in Neuroendocrinology·G Molina-SalinasM Cerbon

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