Prolactin Receptor Expression is an Independent Favorable Prognostic Marker in Human Breast Cancer

Applied Immunohistochemistry & Molecular Morphology : AIMM
Ibrahim Y HachimSuhad Ali

Abstract

Prolactin (PRL) hormone plays an important role in the development of the mammary gland and terminal differentiation of the mammary epithelial cells. While initial studies suggested that PRL may contribute to the development of breast cancer through PRL/prolactin receptor (PRLR) autocrine function, mounting evidence indicate a different role for PRL, highlighting this hormone as a regulator of epithelial plasticity and as a potential tumor suppressor. To gain further insights into the role of PRL in human breast carcinogenesis, immunohistochemistry analyses of PRLR protein expression levels using tissue microarray of 102 cases were done in comparison with various clinical/pathologic parameters and molecular subtypes. In addition, gene expression level of PRLR was also evaluated in relation to intrinsic molecular subtypes, tumor grade, and patient outcome using GOBO database for 1881 breast cancer patients. Interestingly, PRLR expression was found to be significantly downregulated in invasive breast cancer (21.4%) in comparison with normal/benign (80%) and in situ carcinoma (60%) (P=0.003498). Moreover, PRLR expression was associated with lymph node negativity and low-grade well-differentiated tumors. PRLR expression was stronge...Continue Reading

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Citations

Oct 25, 2016·Human Pathology·Ibrahim Y HachimJean-Jacques Lebrun
Sep 24, 2016·Journal of Molecular Endocrinology·Carrie S Shemanko
Oct 27, 2016·International Journal of Molecular Sciences·Carrie S ShemankoAmanda Forsyth
Jan 15, 2019·Endocrine-related Cancer·Vanessa M López-OzunaSuhad Ali
Jan 13, 2018·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Mahmood Y HachimJean-Jacques Lebrun
Mar 3, 2020·Biomedit︠s︡inskai︠a︡ khimii︠a︡·T S KalininaL F Gulyaeva
May 15, 2020·Molecular and Cellular Endocrinology·Sean M HolloranChristy R Hagan
Apr 20, 2021·General and Comparative Endocrinology·Pamela ParéMaria Cátira Bortolini
Oct 29, 2020·Seminars in Cell & Developmental Biology·Ödül Karayazi AtıcıCarrie S Shemanko
Oct 16, 2021·Journal of Cellular and Molecular Medicine·Yuan LiYen-Hua Huang

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