Prolactin receptor gene expression in the brain and peripheral tissues in broody and nonbroody breeds of domestic hen

General and Comparative Endocrinology
T OhkuboP J Sharp

Abstract

The objective of this study was to establish whether the gene encoding prolactin receptor (PRLR) is expressed in the hypothalamus and peripheral tissues of the domestic chicken and, if so, to determine whether there are breed differences in the structure or expression of the gene which might account for the observation that broodiness does not occur in the White Leghorn hen but does occur in other breeds of domestic hens, including the bantam. A preliminary experiment demonstrated that the absence of broodiness in White Leghorns is not due to a lack of a prolactin response to the avian prolactin-releasing hormone vasoactive intestinal polypeptide. The largest amounts of PRLR mRNA in the brain, which did not differ significantly between laying White Leghorns and bantams, were found in the pituitary gland and basal and preoptic hypothalamus. Small or nondetectable amounts were found in both breeds in the forebrain, cerebellum, and optic lobes. Prolactin receptor mRNA was widely distributed in peripheral tissues in both breeds, in the following descending order of abundance: kidney, leg skin, brood patch, duodenum, intestine > thyroid gland > adrenal gland, liver, ovary > adipose tissue > thymus, spleen > muscle > blood. Southern ...Continue Reading

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Citations

Jun 1, 2000·Development, Growth & Differentiation·T YamamotoA Kawahara
Aug 14, 2013·Journal of Molecular Endocrinology·Guixian BuYajun Wang
Sep 10, 2008·Yi chuan = Hereditas·Xiao-Hong ChuYa-Qin Wang
Sep 8, 2007·Canadian Journal of Physiology and Pharmacology·Narattaphol Charoenphandhu, Nateetip Krishnamra
Sep 1, 2015·Theriogenology·Małgorzata Gumułka, Israel Rozenboim
Feb 17, 2015·General and Comparative Endocrinology·Guixian BuYajun Wang
Oct 23, 2016·General and Comparative Endocrinology·Ewa OcłońArieh Gertler
Sep 9, 2000·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·D MangouraD X Wang
Jul 17, 2019·Animal Science Journal = Nihon Chikusan Gakkaihō·Misa Takeda, Takeshi Ohkubo
Nov 14, 1998·The American Journal of Physiology·C C LuP S Wang
Nov 8, 2020·General and Comparative Endocrinology·Kristina O SmileyElizabeth Adkins-Regan

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