Prolactin receptor is associated with c-src kinase in rat liver

Molecular Endocrinology
J J BerlangaJ P García-Ruiz

Abstract

The mechanism of action of the pituitary hormone PRL was studied in hepatocytes of lactating rats. PRL receptor immune complexes obtained from liver lysates have an associated tyrosine kinase activity. The tyrosine kinase has been identified in isolated hepatocytes as pp60c-src. Incubation of hepatocytes with PRL induces the association of PRL receptor with pp60c-src and the resultant stimulation of its tyrosine kinase activity. Furthermore, PRL stimulates the gene expression of c-fos, c-jun, and c-src. All of these findings support the idea that the pp60c-src tyrosine kinase participates in the early steps of the PRL intracellular signaling that promotes cell growth in liver cells.

Citations

Dec 22, 1999·The Biochemical Journal·J A Fresno VaraJ Martín-Pérez
Jul 14, 2001·Molecular Biology of the Cell·J A Fresno VaraJ Martín-Pérez
Jul 19, 2006·Molecular and Cellular Biology·Jeanette NilssonMarie Kannius-Janson
May 11, 2011·The Journal of Clinical Investigation·Yingjie WuDerek LeRoith
Feb 18, 2003·Endocrine Reviews·Charles V ClevengerLinda A Schuler
Jun 6, 2015·Biochemical and Biophysical Research Communications·Alan HammerMaria Diakonova
Feb 22, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Bibiana Moreno-CarranzaCarmen Clapp
Aug 3, 2004·Oncogene·María Aurora Domínguez-CáceresJorge Martín-Pérez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.