Prolactin regulates liver growth during postnatal development in mice

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Bibiana Moreno-CarranzaCarmen Clapp

Abstract

The liver grows during the early postnatal period first at slower and then at faster rates than the body to achieve the adult liver-to-body weight ratio (LBW), a constant reflecting liver health. The hormone prolactin (PRL) stimulates adult liver growth and regeneration, and its levels are high in the circulation of newborn infants, but whether PRL plays a role in neonatal liver growth is unknown. Here, we show that the liver produces PRL and upregulates the PRL receptor in mice during the first 2 wk after birth, when liver growth lags behind body growth. At postnatal week 4, the production of PRL by the liver ceases coinciding with the elevation of circulating PRL and the faster liver growth that catches up with body growth. PRL receptor null mice ( Prlr-/-) show a significant decrease in the LBW at 1, 4, 6, and 10 postnatal weeks and reduced liver expression of proliferation [cyclin D1 ( Ccnd1)] and angiogenesis [platelet/endothelial cell adhesion molecule 1 ( Pecam1)] markers relative to Prlr+/+ mice. However, the LBW increases in Prlr-/- mice at postnatal week 2 concurring with the enhanced liver expression of Igf-1 and the liver upregulation and downregulation of suppressor of cytokine signaling 2 ( Socs2) and Socs3, respe...Continue Reading

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Citations

May 26, 2020·Journal of Neuroendocrinology·Miguel Vázquez-MembrilloCarmen Clapp
Nov 18, 2018·The Journal of Endocrinology·Kok Lim KuaAndrew W Norris
Oct 31, 2020·General and Comparative Endocrinology·Rebeca CoronaTeresa Morales
Jan 20, 2021·Journal of Neuroendocrinology·Felicitas Lopez-VicchiDamasia Becu-Villalobos
Apr 24, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Clemente García-RizoBenedicto Crespo-Facorro

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