PMID: 43786Dec 1, 1979

Prolactin release by intravenous cimetidine in man: evidence for a suprapituitary locus on action

Clinical Endocrinology
C FerrariM Romussi

Abstract

In an attempt to identify the sites at which cimetidine stimulates prolactin release, the drug was administered intravenously (6 mg/kg body weight) to healthy subjects under basal conditions, during dopamine infusion (1 microgram/Kg-min for 120 min) and after pretreatment with L-dopa plus carbidopa (250 plus 25 mg every 6 for 1 day). The serum prolactin response to cimetidine was abolished by dopamine infusion and almost completely suppressed by L-dopa plus carbidopa administration. These findings suggest that the drug acts on the central nervous system to stimulate prolactin release. Although the mechanism of this action is unclear, it does not seem to depend on an antidopaminergic effect and may be related to blackade of brain H2 histamine receptors.

References

Aug 1, 1977·The Journal of Clinical Endocrinology and Metabolism·H E Carlson, A F Ippoliti
Jul 29, 1978·Lancet·G NisticòF Naccari
Dec 1, 1977·Life Sciences·E E MůllerP Mantegazza
Oct 1, 1977·The Journal of Clinical Endocrinology and Metabolism·P G CrosignaniA Caccamo
Oct 1, 1977·The Journal of Clinical Endocrinology and Metabolism·P D WoolfL A Lee
Feb 1, 1978·Acta Endocrinologica·R HorowskiK J Gräf
Jan 1, 1979·Journal of Endocrinological Investigation·R CaldaraC Ferrari
Nov 1, 1977·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·F MinutoG Giordano
Jan 1, 1979·British Journal of Clinical Pharmacology·W L BurlandG V Groom
Jan 1, 1976·Drugs·M T Roberts
Nov 1, 1975·The Journal of Clinical Endocrinology and Metabolism·G S BessesR K Donabedian
Mar 1, 1973·The Journal of Clinical Endocrinology and Metabolism·Y N SinhaW P VanderLaan
Dec 1, 1971·The American Journal of Physiology·W H Oldendorf

Citations

May 1, 1981·Digestive Diseases and Sciences·H E CarlsonR S Swerdloff
Feb 1, 1995·Digestive Diseases and Sciences·R A SmallwoodA Parkinson
Apr 11, 1980·European Journal of Pharmacology·P DevotoP F Spano
Sep 1, 1982·Clinical Endocrinology·J N HuguesE Modigliani
Jan 1, 1981·Journal of Endocrinological Investigation·M IodiceM Minozzi

Related Concepts

Tagamet
Intropin
Guanidines
Histamine H2 Antagonists
Parenteral Infusion
Levopa
Prolactin

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