Prolactin-releasing peptide is a potent mediator of the innate immune response in leukocytes from Salmo salar

Veterinary Immunology and Immunopathology
Alex RomeroJaime Figueroa

Abstract

Prolactin (PRL)-releasing peptide (PrRP) is a strong candidate stimulator of pituitary PRL transcription and secretion in teleosts. However, the role in control of extrapituitary PRL expression or its effects on innate immunity are unclear even in mammals. To study the possible presence of PrRP in peripheral organs, PrRP expression patterns and their effect on innate immunity were characterised in SHK-1 cells and head kidney (HK) leukocytes purified from the salmonid, Salmo salar. We detected immunoreactive cells in leukocytes from blood and HK of S. salar and found that PrRP mRNA was abundantly expressed in these cells. We have recently reported that physiological concentrations of native PRL, downstream of neuropeptide PrRP were able to induce expression of pro-inflammatory cytokines and the production of reactive oxygen species (ROS) in HK leukocytes and macrophages from S. salar and Sparus aurata. It is of interest to note that in this work we have revealed that synthetic PrRP was able to induce expression of pro-inflammatory cytokines (interleukins) IL-1β, IL-6, IL-8, IL-12 and PRL. We also show here that PrRP increased both (ROS) production and phagocytosis. Taken together, our results demonstrate for the first time that ...Continue Reading

References

Nov 1, 1986·General and Comparative Endocrinology·A J de RuiterB Baggerman
Oct 1, 1996·The Journal of Endocrinology·M SakaiH Kawauchi
Jan 4, 2001·Veterinary Immunology and Immunopathology·J Harris, D J Bird
Sep 11, 2001·The Journal of Experimental Zoology·M SakaiA Takahashi
Mar 25, 2006·Cell and Tissue Research·R A Montefusco-SiegmundJ Figueroa
Mar 18, 2008·Journal of Neuroimmunology·Sammy BedouiStephan von Hörsten

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